SPATA5
Gene Information
- Official Symbol: SPATA5
- Official Name: spermatogenesis associated 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 166378
- UniProt: Q8NB90
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: This gene encodes a member of the ATPase associated with diverse activities family, whose members are defined by a highly conserved ATPase domain. Members of this family participate in diverse cellular processes that include membrane fusion, DNA replication, microtubule severing, and protein degradation. The protein encoded by this gene has a putative mitochondrial targeting sequence and has been proposed to function in maintenance of mitochondrial function and integrity during mouse spermatogenesis. Allelic variants in this gene have been associated with epilepsy, hearing loss, and cognitive disability syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
- UniProt Summary: May be involved in morphological and functional mitochondrial transformations during spermatogenesis. {ECO:0000250|UniProtKB:Q3UMC0}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1093
- Expression level (log2 read counts): 5.71
SPATA5 Expression in NALM6 Cells: 5.71
