HPRT1
Gene Information
- Official Symbol: HPRT1
- Official Name: hypoxanthine phosphoribosyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3251
- UniProt: P00492
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009].
- UniProt Summary: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Pfam Domains GO Terms
Pfam Domains
| Pribosyltran |
GO Terms
| guanine phosphoribosyltransferase activity |
| GMP salvage |
| adenine salvage |
| hypoxanthine salvage |
| guanine biosynthetic process |
| guanine salvage |
| GMP catabolic process |
| hypoxanthine phosphoribosyltransferase activity |
| hypoxanthine biosynthetic process |
| adenine biosynthetic process |
| hypoxanthine metabolic process |
| adenine metabolic process |
| purine ribonucleoside monophosphate catabolic process |
| guanosine-containing compound catabolic process |
| IMP salvage |
| guanine metabolic process |
| GMP biosynthetic process |
| ribonucleoside monophosphate catabolic process |
| purine nucleobase salvage |
| purine nucleoside monophosphate catabolic process |
| purine ribonucleoside salvage |
| positive regulation of dopamine metabolic process |
| positive regulation of catecholamine metabolic process |
| nucleoside monophosphate catabolic process |
| purine nucleotide salvage |
| positive regulation of cellular amine metabolic process |
| IMP biosynthetic process |
| purine ribonucleoside catabolic process |
| purine nucleoside catabolic process |
| purine nucleobase biosynthetic process |
| IMP metabolic process |
| nucleotide salvage |
| guanosine-containing compound biosynthetic process |
| grooming behavior |
| GMP metabolic process |
| purine-containing compound salvage |
| nucleoside salvage |
| striatum development |
| T cell mediated cytotoxicity |
| purine nucleoside monophosphate biosynthetic process |
| purine ribonucleoside monophosphate biosynthetic process |
| regulation of catecholamine metabolic process |
| nucleobase biosynthetic process |
| regulation of dopamine metabolic process |
| purine nucleobase metabolic process |
| ribonucleoside biosynthetic process |
| purine ribonucleoside biosynthetic process |
| purine nucleoside biosynthetic process |
| ribonucleoside catabolic process |
| subpallium development |
| cerebral cortex neuron differentiation |
| dopamine metabolic process |
| response to amphetamine |
| purine ribonucleotide catabolic process |
| ribonucleotide catabolic process |
| ribonucleoside monophosphate biosynthetic process |
| cellular metabolic compound salvage |
| nucleoside catabolic process |
| purine ribonucleoside monophosphate metabolic process |
| purine nucleoside monophosphate metabolic process |
| nucleoside biosynthetic process |
| leukocyte mediated cytotoxicity |
| guanosine-containing compound metabolic process |
| T cell mediated immunity |
| glycosyl compound biosynthetic process |
| nucleobase metabolic process |
| catecholamine metabolic process |
| nucleoside monophosphate biosynthetic process |
| catechol-containing compound metabolic process |
| purine nucleotide catabolic process |
| glycosyl compound catabolic process |
| response to amine |
| pigment biosynthetic process |
| nucleobase-containing small molecule catabolic process |
| response to bronchodilator |
| ribonucleoside monophosphate metabolic process |
| purine-containing compound catabolic process |
| dendrite morphogenesis |
| purine ribonucleoside metabolic process |
| nucleotide binding |
| purine nucleoside metabolic process |
| pigment metabolic process |
| nucleotide catabolic process |
| nucleoside phosphate catabolic process |
| nucleoside monophosphate metabolic process |
| ribonucleoside metabolic process |
| central nervous system neuron development |
| regulation of cellular amine metabolic process |
| phenol-containing compound metabolic process |
| lymphocyte proliferation |
| mononuclear cell proliferation |
| cell killing |
| protein homotetramerization |
| leukocyte proliferation |
| dendrite development |
| nucleobase-containing small molecule biosynthetic process |
| nucleoside metabolic process |
| organophosphate catabolic process |
| glycosyl compound metabolic process |
| purine ribonucleotide biosynthetic process |
| protein tetramerization |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| central nervous system neuron differentiation |
| carbohydrate derivative catabolic process |
| ammonium ion metabolic process |
| locomotory behavior |
| magnesium ion binding |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| telencephalon development |
| lymphocyte mediated immunity |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| response to xenobiotic stimulus |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| protein homooligomerization |
| purine-containing compound metabolic process |
| nucleobase-containing compound catabolic process |
| lymphocyte activation |
| forebrain development |
| cell morphogenesis involved in neuron differentiation |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| small molecule catabolic process |
| aromatic compound catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic hydroxy compound metabolic process |
| organic cyclic compound catabolic process |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| drug metabolic process |
| response to toxic substance |
| cell part morphogenesis |
| protein complex oligomerization |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| behavior |
| small molecule biosynthetic process |
| adaptive immune response |
| carbohydrate derivative biosynthetic process |
| neuron projection development |
| cell morphogenesis |
| brain development |
| leukocyte mediated immunity |
| head development |
| neuron development |
| cellular component morphogenesis |
| protein homodimerization activity |
| organophosphate metabolic process |
| leukocyte activation |
| central nervous system development |
| response to organonitrogen compound |
| neuron differentiation |
| response to drug |
| carbohydrate derivative metabolic process |
| organonitrogen compound catabolic process |
| identical protein binding |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| nucleobase-containing compound biosynthetic process |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| generation of neurons |
| protein-containing complex assembly |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| cell development |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11418
- Expression level (log2 read counts): 5.71
Expression Distribution
HPRT1 Expression in NALM6 Cells: 5.71
