HPRT1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= HPRT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HPRT1
  * **<color #00a2e8>Official Name</color>**: hypoxanthine phosphoribosyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3251|3251]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00492|P00492]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HPRT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HPRT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/308000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pribosyltran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|guanine phosphoribosyltransferase activity|
|GMP salvage|
|adenine salvage|
|hypoxanthine salvage|
|guanine biosynthetic process|
|guanine salvage|
|GMP catabolic process|
|hypoxanthine phosphoribosyltransferase activity|
|hypoxanthine biosynthetic process|
|adenine biosynthetic process|
|hypoxanthine metabolic process|
|adenine metabolic process|
|purine ribonucleoside monophosphate catabolic process|
|guanosine-containing compound catabolic process|
|IMP salvage|
|guanine metabolic process|
|GMP biosynthetic process|
|ribonucleoside monophosphate catabolic process|
|purine nucleobase salvage|
|purine nucleoside monophosphate catabolic process|
|purine ribonucleoside salvage|
|positive regulation of dopamine metabolic process|
|positive regulation of catecholamine metabolic process|
|nucleoside monophosphate catabolic process|
|purine nucleotide salvage|
|positive regulation of cellular amine metabolic process|
|IMP biosynthetic process|
|purine ribonucleoside catabolic process|
|purine nucleoside catabolic process|
|purine nucleobase biosynthetic process|
|IMP metabolic process|
|nucleotide salvage|
|guanosine-containing compound biosynthetic process|
|grooming behavior|
|GMP metabolic process|
|purine-containing compound salvage|
|nucleoside salvage|
|striatum development|
|T cell mediated cytotoxicity|
|purine nucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate biosynthetic process|
|regulation of catecholamine metabolic process|
|nucleobase biosynthetic process|
|regulation of dopamine metabolic process|
|purine nucleobase metabolic process|
|ribonucleoside biosynthetic process|
|purine ribonucleoside biosynthetic process|
|purine nucleoside biosynthetic process|
|ribonucleoside catabolic process|
|subpallium development|
|cerebral cortex neuron differentiation|
|dopamine metabolic process|
|response to amphetamine|
|purine ribonucleotide catabolic process|
|ribonucleotide catabolic process|
|ribonucleoside monophosphate biosynthetic process|
|cellular metabolic compound salvage|
|nucleoside catabolic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleoside biosynthetic process|
|leukocyte mediated cytotoxicity|
|guanosine-containing compound metabolic process|
|T cell mediated immunity|
|glycosyl compound biosynthetic process|
|nucleobase metabolic process|
|catecholamine metabolic process|
|nucleoside monophosphate biosynthetic process|
|catechol-containing compound metabolic process|
|purine nucleotide catabolic process|
|glycosyl compound catabolic process|
|response to amine|
|pigment biosynthetic process|
|nucleobase-containing small molecule catabolic process|
|response to bronchodilator|
|ribonucleoside monophosphate metabolic process|
|purine-containing compound catabolic process|
|dendrite morphogenesis|
|purine ribonucleoside metabolic process|
|nucleotide binding|
|purine nucleoside metabolic process|
|pigment metabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|central nervous system neuron development|
|regulation of cellular amine metabolic process|
|phenol-containing compound metabolic process|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|cell killing|
|protein homotetramerization|
|leukocyte proliferation|
|dendrite development|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|organophosphate catabolic process|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|protein tetramerization|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|central nervous system neuron differentiation|
|carbohydrate derivative catabolic process|
|ammonium ion metabolic process|
|locomotory behavior|
|magnesium ion binding|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|telencephalon development|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to xenobiotic stimulus|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein homooligomerization|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|lymphocyte activation|
|forebrain development|
|cell morphogenesis involved in neuron differentiation|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|drug metabolic process|
|response to toxic substance|
|cell part morphogenesis|
|protein complex oligomerization|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|behavior|
|small molecule biosynthetic process|
|adaptive immune response|
|carbohydrate derivative biosynthetic process|
|neuron projection development|
|cell morphogenesis|
|brain development|
|leukocyte mediated immunity|
|head development|
|neuron development|
|cellular component morphogenesis|
|protein homodimerization activity|
|organophosphate metabolic process|
|leukocyte activation|
|central nervous system development|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-3.15|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.9|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-2.6|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.59|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.59|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.44|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.34|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.34|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.23|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.12|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.06|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.05|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.91|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.87|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.85|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.72|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.77|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.79|
|[[:results:exp302|35°C R06 exp302]]|1.87|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.23|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|6.54|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|8.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11418
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HPRT1 Expression in NALM6 Cells: 5.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>