MAPK6

Entrez Summary: N/A
UniProt Summary: Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotine 3000μM R08 exp510	-1.92
2-Deoxy-D-glucose 800μM R05 exp214	1.73
Artemisinin 50μM R08 exp450	1.86
ML-792 0.2μM R08 exp505	1.92
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.95
Aphidicolin 0.4μM R08 exp440	2.05
Benzoate 20000μM R08 exp456	2.77

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase Tyr
Pkinase

septin cytoskeleton
MAP kinase activity
positive regulation of dendritic spine development
positive regulation of dendrite development
regulation of dendritic spine development
regulation of dendrite development
positive regulation of neuron projection development
protein serine/threonine kinase activity
positive regulation of neuron differentiation
MAPK cascade
positive regulation of cell projection organization
signal transduction by protein phosphorylation
protein kinase binding
positive regulation of neurogenesis
protein heterodimerization activity
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
protein-containing complex
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
protein phosphorylation
positive regulation of cellular component organization
phosphorylation
cell cycle
positive regulation of developmental process
ATP binding
generation of neurons
neurogenesis
intracellular signal transduction
positive regulation of multicellular organismal process
regulation of cell differentiation