PHF15

Entrez Summary: N/A
UniProt Summary: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo (PubMed:16387653). Acts as a E3 ubiquitin- protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 1μM R00 exp29	-2.26
Benzoate 20000μM R08 exp456	-2.03
Chloramphenicol 20μM R00 exp13	-2
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.87
Doxycycline 10μM R00 exp18	-1.86
Menadione 5μM R06 exp292	-1.8
Vemurafenib 6.6μM R02 exp89	-1.74
Deguelin 0.15μM R05 exp209	-1.71
MS094 2μM R03 exp136	1.72
BI-6727 0.0125μM R03 exp97	2.08
Mdivi-1 15μM R05 exp217	3.04

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PHD
EPL1

histone H4-K12 acetylation
histone H4-K8 acetylation
histone H4-K5 acetylation
histone H4-K16 acetylation
histone acetyltransferase complex
histone H3 acetylation
histone H4 acetylation
transferase activity
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
protein acylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
protein ubiquitination
chromatin organization
protein modification by small protein conjugation
peptidyl-amino acid modification
protein modification by small protein conjugation or removal
chromosome organization