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Ask your administrator if you think this is wrong. ====== Benzoate 20000μM R08 exp456 ====== ==== Mechanism of Action ==== Food additive (E211), bacteriostatic and fungistatic * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Food Preservative ==== Technical Notes ==== <accordion collapsed='true'> <panel title='Compound References' collapsed='true'> * **<color #00a2e8>PubChem Name:</color>** %%Sodium benzoate%% * **<color #00a2e8>Synonyms:</color>** N/A * **<color #00a2e8>CAS #:</color>** 532-32-1 * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/517055|517055]] * **<color #00a2e8>IUPAC:</color>** %%sodium;benzoate%% * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1 * **<color #00a2e8>INCHI Key:</color>** WXMKPNITSTVMEF-UHFFFAOYSA-M * **<color #00a2e8>Molecular Weight:</color>** 144.1 * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C(C=C1)C(=O)[O-].[Na+] * **<color #00a2e8>Isomeric SMILES:</color>** N/A * **<color #00a2e8>Molecular Formula:</color>** C7H5O2Na {{:chemogenomics:structures:chem-0266.svg?nolink}} </panel> <panel title='Compound Supplier' collapsed='true'> * **<color #00a2e8>Supplier Name:</color>** Med Chem Express * **<color #00a2e8>Catalog #:</color>** HY-Y1316 * **<color #00a2e8>Lot #:</color>** 26735 </panel> <panel title='Compound Characterization' collapsed='true'> * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+Na)+ Calcd for C7H6O2 145.026; found 145.02692 </panel> <panel title='Dose Response Curve' collapsed='true'> * **<color #00a2e8>Platform ID:</color>** Benzoate * **<color #00a2e8>Min:</color>** -0.6897; **<color #00a2e8>Max:</color>** 28.0815 {{:chemogenomics:dose_response:dr_503.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |N/A | | IC20 |N/A | | IC30 |N/A | | IC40 |N/A | | IC50 |N/A | | IC60 |N/A | | IC70 |N/A | | IC80 |N/A | | IC90 |N/A | \\ </panel> </accordion> ==== Screen Summary ==== * **<color #00a2e8>Round</color>**: 08 * **<color #00a2e8>Dose</color>**: 20000µM * **<color #00a2e8>Days of incubation</color>**: 8 * **<color #00a2e8>Doublings</color>**: -0.0 * **<color #00a2e8>Numbers of reads</color>**: 15983785 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |0/63|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Benzoate_20000uM_Round-8_exp456.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>| <modal id='ScorePlot' size='lg' title='Benzoate 20000μM R08 exp456'> {{:chemogenomics:cranks_plots:exp456.png?nolink}} </modal> <modal id="modal_hits" size="sm" title="Top 30 S/R Genes"> ^Gene^CRANKS Score^FDR^ |[[:human_genes:L:LHFP|LHFP]]|-2.62|0.20| |[[:human_genes:H:HMGCR|HMGCR]]|-2.45|0.53| |[[:human_genes:E:EXOSC3|EXOSC3]]|-2.40|0.28| |[[:human_genes:D:DNM2|DNM2]]|-2.38|0.67| |[[:human_genes:M:METTL13|METTL13]]|-2.36|0.22| |[[:human_genes:Z:ZNF106|ZNF106]]|-2.34|0.22| |[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.33|0.22| |[[:human_genes:C:CCIN|CCIN]]|-2.33|0.22| |[[:human_genes:N:NFS1|NFS1]]|-2.31|0.67| |[[:human_genes:G:GTF2B|GTF2B]]|-2.27|0.65| |[[:human_genes:P:PPM1G|PPM1G]]|-2.26|0.37| |[[:human_genes:S:SYNCRIP|SYNCRIP]]|-2.26|0.53| |[[:human_genes:S:SUPT6H|SUPT6H]]|-2.21|0.53| |[[:human_genes:Z:ZDHHC2|ZDHHC2]]|-2.21|0.32| |[[:human_genes:L:LOC81691|LOC81691]]|-2.19|0.53| |[[:human_genes:N:NID2|NID2]]|-2.17|0.34| |[[:human_genes:S:SH3BP1|SH3BP1]]|-2.12|0.53| |[[:human_genes:P:PNPLA2|PNPLA2]]|-2.12|0.37| |[[:human_genes:C:COL2A1|COL2A1]]|-2.08|0.53| |[[:human_genes:P:PHF15|PHF15]]|-2.03|0.53| |[[:human_genes:M:MEF2D|MEF2D]]|-2.03|0.53| |[[:human_genes:C:CNOT3|CNOT3]]|-2.02|0.61| |[[:human_genes:V:VPREB1|VPREB1]]|-2.02|0.53| |[[:human_genes:R:RPS23|RPS23]]|-2.01|0.53| |[[:human_genes:N:NUP43|NUP43]]|-2.01|0.53| |[[:human_genes:S:SMG5|SMG5]]|-1.99|0.75| |[[:human_genes:P:PSKH1|PSKH1]]|-1.98|0.53| |[[:human_genes:M:MAU2|MAU2]]|-1.97|0.75| |[[:human_genes:K:KIAA1549|KIAA1549]]|-1.96|0.53| |[[:human_genes:S:SF3A1|SF3A1]]|-1.95|0.67| |[[:human_genes:M:MAPKAPK5|MAPKAPK5]]|2.96|<0.01| |[[:human_genes:S:SLC4A7|SLC4A7]]|2.96|<0.01| |[[:human_genes:C:CD19|CD19]]|2.98|<0.01| |[[:human_genes:K:KCTD5|KCTD5]]|2.99|0.00| |[[:human_genes:D:DOHH|DOHH]]|2.99|<0.01| |[[:human_genes:H:HCCS|HCCS]]|3.02|<0.01| |[[:human_genes:A:ALAS1|ALAS1]]|3.12|<0.01| |[[:human_genes:F:FLCN|FLCN]]|3.14|0.00| |[[:human_genes:C:CD81|CD81]]|3.15|0.00| |[[:human_genes:T:THG1L|THG1L]]|3.19|0.00| |[[:human_genes:L:LAMTOR4|LAMTOR4]]|3.30|0.00| |[[:human_genes:M:MLST8|MLST8]]|3.32|0.00| |[[:human_genes:B:BCL2L11|BCL2L11]]|3.40|0.00| |[[:human_genes:T:TAF4|TAF4]]|3.45|0.00| |[[:human_genes:G:GMPPB|GMPPB]]|3.70|<0.01| |[[:human_genes:C:CASP9|CASP9]]|3.70|0.00| |[[:human_genes:R:RICTOR|RICTOR]]|3.90|0.00| |[[:human_genes:M:MS4A13|MS4A13]]|3.91|0.02| |[[:human_genes:G:GNAS|GNAS]]|3.96|0.00| |[[:human_genes:M:MAPKAP1|MAPKAP1]]|4.04|0.00| |[[:human_genes:M:MCL1|MCL1]]|4.44|0.00| |[[:human_genes:A:APAF1|APAF1]]|4.55|0.00| |[[:human_genes:P:PLAA|PLAA]]|4.69|0.00| |[[:human_genes:A:AHCYL1|AHCYL1]]|5.07|0.00| |[[:human_genes:N:NSD1|NSD1]]|5.07|0.00| |[[:human_genes:F:FAF2|FAF2]]|5.36|0.00| |[[:human_genes:V:VDAC2|VDAC2]]|6.41|0.00| |[[:human_genes:U:UBQLN1|UBQLN1]]|6.91|0.00| |[[:human_genes:B:BAK1|BAK1]]|7.87|0.00| |[[:human_genes:M:MARCH5|MARCH5]]|7.88|0.00| </modal> <modal id="modal_screen_similarity" size="lg" title="Correlated Screens"> ^Screen^Correlation^Plot^ |[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.166|<button type="primary" size="small" modal="1">View</button>| |[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.162|<button type="primary" size="small" modal="2">View</button>| |[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.156|<button type="primary" size="small" modal="3">View</button>| |[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.149|<button type="primary" size="small" modal="4">View</button>| |[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.142|<button type="primary" size="small" modal="5">View</button>| |[[:results:exp135|MS023 7μM R03 exp135]]|0.139|<button type="primary" size="small" modal="6">View</button>| |[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.137|<button type="primary" size="small" modal="7">View</button>| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.136|<button type="primary" size="small" modal="8">View</button>| |[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.132|<button type="primary" size="small" modal="9">View</button>| |[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.13|<button type="primary" size="small" modal="10">View</button>| |[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.122|<button type="primary" size="small" modal="11">View</button>| |[[:results:exp443|SNS-032 15μM R08 exp443]]|0.117|<button type="primary" size="small" modal="12">View</button>| |[[:results:exp512|Olaparib 4μM R08 exp512]]|0.113|<button type="primary" size="small" modal="13">View</button>| |[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.111|<button type="primary" size="small" modal="14">View</button>| |[[:results:exp134|MS023 2μM R03 exp134]]|0.108|<button type="primary" size="small" modal="15">View</button>| |[[:results:exp34|Rotenone 20μM R00 exp34]]|0.107|<button type="primary" size="small" modal="16">View</button>| |[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.103|<button type="primary" size="small" modal="17">View</button>| |[[:results:exp485|GSK626616 14μM R08 exp485]]|0.101|<button type="primary" size="small" modal="18">View</button>| |[[:results:exp19|Etoposide 1μM R00 exp19]]|0.1|<button type="primary" size="small" modal="19">View</button>| |[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.097|<button type="primary" size="small" modal="20">View</button>| |[[:results:exp515|PU-H71 1μM R08 exp515]]|0.095|<button type="primary" size="small" modal="21">View</button>| |[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.086|<button type="primary" size="small" modal="22">View</button>| |[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.085|<button type="primary" size="small" modal="23">View</button>| |[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.084|<button type="primary" size="small" modal="24">View</button>| |[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.083|<button type="primary" size="small" modal="25">View</button>| |[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.082|<button type="primary" size="small" modal="26">View</button>| |[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.079|<button type="primary" size="small" modal="27">View</button>| |[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.078|<button type="primary" size="small" modal="28">View</button>| |[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.075|<button type="primary" size="small" modal="29">View</button>| |[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.072|<button type="primary" size="small" modal="30">View</button>| |[[:results:exp85|UM0129480 7μM R02 exp85]]|0.07|<button type="primary" size="small" modal="31">View</button>| |[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.068|<button type="primary" size="small" modal="32">View</button>| |[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.066|<button type="primary" size="small" modal="33">View</button>| |[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.065|<button type="primary" size="small" modal="34">View</button>| |[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.059|<button type="primary" size="small" modal="35">View</button>| |[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.059|<button type="primary" size="small" modal="36">View</button>| |[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.058|<button type="primary" size="small" modal="37">View</button>| |[[:results:exp517|Quercetin 20μM R08 exp517]]|0.058|<button type="primary" size="small" modal="38">View</button>| |[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.057|<button type="primary" size="small" modal="39">View</button>| |[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.056|<button type="primary" size="small" modal="40">View</button>| |[[:results:exp93|DABN racemic mixture R03 exp93]]|0.055|<button type="primary" size="small" modal="41">View</button>| |[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.054|<button type="primary" size="small" modal="42">View</button>| |[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.052|<button type="primary" size="small" modal="43">View</button>| |[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.052|<button type="primary" size="small" modal="44">View</button>| |[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.051|<button type="primary" size="small" modal="45">View</button>| |[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.051|<button type="primary" size="small" modal="46">View</button>| |[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.16|<button type="primary" size="small" modal="47">View</button>| |[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.153|<button type="primary" size="small" modal="48">View</button>| |[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.152|<button type="primary" size="small" modal="49">View</button>| |[[:results:exp211|AICAR 240μM R05 exp211]]|0.128|<button type="primary" size="small" modal="50">View</button>| |[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.127|<button type="primary" size="small" modal="51">View</button>| |[[:results:exp116|AICAR 240μM R03 exp116]]|0.104|<button type="primary" size="small" modal="52">View</button>| |[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.096|<button type="primary" size="small" modal="53">View</button>| |[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.075|<button type="primary" size="small" modal="54">View</button>| |[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.072|<button type="primary" size="small" modal="55">View</button>| |[[:results:exp539|42°C R08 exp539]]|0.062|<button type="primary" size="small" modal="56">View</button>| </modal> <modal id="1" size="lg" title="Benzoate 20000μM R08 exp456 vs Bleomycin 5μM R08 exp459"> {{:chemogenomics:comparison_plots:exp456_vs_exp459.png?nolink |}} </modal> <modal id="2" size="lg" title="Benzoate 20000μM R08 exp456 vs Etoposide 0.3μM R05 exp199"> {{:chemogenomics:comparison_plots:exp199_vs_exp456.png?nolink |}} </modal> <modal id="3" size="lg" title="Benzoate 20000μM R08 exp456 vs Mitomycin-C 0.06μM R08 exp503"> {{:chemogenomics:comparison_plots:exp456_vs_exp503.png?nolink |}} </modal> <modal id="4" size="lg" title="Benzoate 20000μM R08 exp456 vs Hippuristanol 0.12μM R08 exp489 no dilution day6"> {{:chemogenomics:comparison_plots:exp456_vs_exp489.png?nolink |}} </modal> <modal id="5" size="lg" title="Benzoate 20000μM R08 exp456 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp456_vs_exp488.png?nolink |}} </modal> <modal id="6" size="lg" title="Benzoate 20000μM R08 exp456 vs MS023 7μM R03 exp135"> {{:chemogenomics:comparison_plots:exp135_vs_exp456.png?nolink |}} </modal> <modal id="7" size="lg" title="Benzoate 20000μM R08 exp456 vs RO-3307 4.7μM R02 exp80"> {{:chemogenomics:comparison_plots:exp456_vs_exp80.png?nolink |}} </modal> <modal id="8" size="lg" title="Benzoate 20000μM R08 exp456 vs THZ1 0.06μM R08 exp531"> {{:chemogenomics:comparison_plots:exp456_vs_exp531.png?nolink |}} </modal> <modal id="9" size="lg" title="Benzoate 20000μM R08 exp456 vs Staurosporine 0.02μM R08 exp524"> {{:chemogenomics:comparison_plots:exp456_vs_exp524.png?nolink |}} </modal> <modal id="10" size="lg" title="Benzoate 20000μM R08 exp456 vs CI-1040 9.5μM R08 exp472"> {{:chemogenomics:comparison_plots:exp456_vs_exp472.png?nolink |}} </modal> <modal id="11" size="lg" title="Benzoate 20000μM R08 exp456 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp456_vs_exp478.png?nolink |}} </modal> <modal id="12" size="lg" title="Benzoate 20000μM R08 exp456 vs SNS-032 15μM R08 exp443"> {{:chemogenomics:comparison_plots:exp443_vs_exp456.png?nolink |}} </modal> <modal id="13" size="lg" title="Benzoate 20000μM R08 exp456 vs Olaparib 4μM R08 exp512"> {{:chemogenomics:comparison_plots:exp456_vs_exp512.png?nolink |}} </modal> <modal id="14" size="lg" title="Benzoate 20000μM R08 exp456 vs Pimelic-diphenylamide-106 5μM R00 exp28"> {{:chemogenomics:comparison_plots:exp28_vs_exp456.png?nolink |}} </modal> <modal id="15" size="lg" title="Benzoate 20000μM R08 exp456 vs MS023 2μM R03 exp134"> {{:chemogenomics:comparison_plots:exp134_vs_exp456.png?nolink |}} </modal> <modal id="16" size="lg" title="Benzoate 20000μM R08 exp456 vs Rotenone 20μM R00 exp34"> {{:chemogenomics:comparison_plots:exp34_vs_exp456.png?nolink |}} </modal> <modal id="17" size="lg" title="Benzoate 20000μM R08 exp456 vs Dinaciclib 0.007μM R07 exp355"> {{:chemogenomics:comparison_plots:exp355_vs_exp456.png?nolink |}} </modal> <modal id="18" size="lg" title="Benzoate 20000μM R08 exp456 vs GSK626616 14μM R08 exp485"> {{:chemogenomics:comparison_plots:exp456_vs_exp485.png?nolink |}} </modal> <modal id="19" size="lg" title="Benzoate 20000μM R08 exp456 vs Etoposide 1μM R00 exp19"> {{:chemogenomics:comparison_plots:exp19_vs_exp456.png?nolink |}} </modal> <modal id="20" size="lg" title="Benzoate 20000μM R08 exp456 vs Ethanol 0.01 R05 exp234"> {{:chemogenomics:comparison_plots:exp234_vs_exp456.png?nolink |}} </modal> <modal id="21" size="lg" title="Benzoate 20000μM R08 exp456 vs PU-H71 1μM R08 exp515"> {{:chemogenomics:comparison_plots:exp456_vs_exp515.png?nolink |}} </modal> <modal id="22" size="lg" title="Benzoate 20000μM R08 exp456 vs Tanespimycin 14μM R08 exp527"> {{:chemogenomics:comparison_plots:exp456_vs_exp527.png?nolink |}} </modal> <modal id="23" size="lg" title="Benzoate 20000μM R08 exp456 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp456.png?nolink |}} </modal> <modal id="24" size="lg" title="Benzoate 20000μM R08 exp456 vs CR131-b 0.005μM R08 exp474"> {{:chemogenomics:comparison_plots:exp456_vs_exp474.png?nolink |}} </modal> <modal id="25" size="lg" title="Benzoate 20000μM R08 exp456 vs MLN-4924 2μM R00 exp22"> {{:chemogenomics:comparison_plots:exp22_vs_exp456.png?nolink |}} </modal> <modal id="26" size="lg" title="Benzoate 20000μM R08 exp456 vs MLN-4924 0.2μM R00 exp21"> {{:chemogenomics:comparison_plots:exp21_vs_exp456.png?nolink |}} </modal> <modal id="27" size="lg" title="Benzoate 20000μM R08 exp456 vs Sulforaphane 9μM R08 exp526 no dilution day6"> {{:chemogenomics:comparison_plots:exp456_vs_exp526.png?nolink |}} </modal> <modal id="28" size="lg" title="Benzoate 20000μM R08 exp456 vs Sulforaphane 9μM R08 exp525"> {{:chemogenomics:comparison_plots:exp456_vs_exp525.png?nolink |}} </modal> <modal id="29" size="lg" title="Benzoate 20000μM R08 exp456 vs JQ1 0.8μM R08 exp435"> {{:chemogenomics:comparison_plots:exp435_vs_exp456.png?nolink |}} </modal> <modal id="30" size="lg" title="Benzoate 20000μM R08 exp456 vs Thimerosal 0.85μM R08 exp529"> {{:chemogenomics:comparison_plots:exp456_vs_exp529.png?nolink |}} </modal> <modal id="31" size="lg" title="Benzoate 20000μM R08 exp456 vs UM0129480 7μM R02 exp85"> {{:chemogenomics:comparison_plots:exp456_vs_exp85.png?nolink |}} </modal> <modal id="32" size="lg" title="Benzoate 20000μM R08 exp456 vs Vinblastine 0.2μM R03 exp108"> {{:chemogenomics:comparison_plots:exp108_vs_exp456.png?nolink |}} </modal> <modal id="33" size="lg" title="Benzoate 20000μM R08 exp456 vs Deferoxamine 11μM R07 exp350"> {{:chemogenomics:comparison_plots:exp350_vs_exp456.png?nolink |}} </modal> <modal id="34" size="lg" title="Benzoate 20000μM R08 exp456 vs GSK461364A 0.1μM R03 exp126"> {{:chemogenomics:comparison_plots:exp126_vs_exp456.png?nolink |}} </modal> <modal id="35" size="lg" title="Benzoate 20000μM R08 exp456 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp456_vs_exp500.png?nolink |}} </modal> <modal id="36" size="lg" title="Benzoate 20000μM R08 exp456 vs UM131593 0.2μM R03 exp106"> {{:chemogenomics:comparison_plots:exp106_vs_exp456.png?nolink |}} </modal> <modal id="37" size="lg" title="Benzoate 20000μM R08 exp456 vs Lead acetate 2000μM R08 exp498 no dilution day6"> {{:chemogenomics:comparison_plots:exp456_vs_exp498.png?nolink |}} </modal> <modal id="38" size="lg" title="Benzoate 20000μM R08 exp456 vs Quercetin 20μM R08 exp517"> {{:chemogenomics:comparison_plots:exp456_vs_exp517.png?nolink |}} </modal> <modal id="39" size="lg" title="Benzoate 20000μM R08 exp456 vs CB-5083 0.4μM R08 exp468"> {{:chemogenomics:comparison_plots:exp456_vs_exp468.png?nolink |}} </modal> <modal id="40" size="lg" title="Benzoate 20000μM R08 exp456 vs Nutlin-3A 1.6μM R06 exp294"> {{:chemogenomics:comparison_plots:exp294_vs_exp456.png?nolink |}} </modal> <modal id="41" size="lg" title="Benzoate 20000μM R08 exp456 vs DABN racemic mixture R03 exp93"> {{:chemogenomics:comparison_plots:exp456_vs_exp93.png?nolink |}} </modal> <modal id="42" size="lg" title="Benzoate 20000μM R08 exp456 vs Lead acetate 2000μM R08 exp497"> {{:chemogenomics:comparison_plots:exp456_vs_exp497.png?nolink |}} </modal> <modal id="43" size="lg" title="Benzoate 20000μM R08 exp456 vs Diepoxybutane 3μM R07 exp354"> {{:chemogenomics:comparison_plots:exp354_vs_exp456.png?nolink |}} </modal> <modal id="44" size="lg" title="Benzoate 20000μM R08 exp456 vs Latrunculin-B 10μM R07 exp374"> {{:chemogenomics:comparison_plots:exp374_vs_exp456.png?nolink |}} </modal> <modal id="45" size="lg" title="Benzoate 20000μM R08 exp456 vs Trimetrexate 0.03μM R08 exp535"> {{:chemogenomics:comparison_plots:exp456_vs_exp535.png?nolink |}} </modal> <modal id="46" size="lg" title="Benzoate 20000μM R08 exp456 vs GSK-J4 1.5μM R08 exp441"> {{:chemogenomics:comparison_plots:exp441_vs_exp456.png?nolink |}} </modal> <modal id="47" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp259_vs_exp456.png?nolink |}} </modal> <modal id="48" size="lg" title="5-Fluorouracil 20μM R00 exp2 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp2_vs_exp456.png?nolink |}} </modal> <modal id="49" size="lg" title="Aphidicolin 0.4μM R08 exp440 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp440_vs_exp456.png?nolink |}} </modal> <modal id="50" size="lg" title="AICAR 240μM R05 exp211 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp211_vs_exp456.png?nolink |}} </modal> <modal id="51" size="lg" title="Actinomycin-D 0.001μM R00 exp3 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp3_vs_exp456.png?nolink |}} </modal> <modal id="52" size="lg" title="AICAR 240μM R03 exp116 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp116_vs_exp456.png?nolink |}} </modal> <modal id="53" size="lg" title="Atovaquone 15μM R08 exp451 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp451_vs_exp456.png?nolink |}} </modal> <modal id="54" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp448_vs_exp456.png?nolink |}} </modal> <modal id="55" size="lg" title="Artemisinin 50μM R08 exp450 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp450_vs_exp456.png?nolink |}} </modal> <modal id="56" size="lg" title="42°C R08 exp539 vs Benzoate 20000μM R08 exp456"> {{:chemogenomics:comparison_plots:exp456_vs_exp539.png?nolink |}} </modal> <modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal> <modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms"> ^GO Term^Fold Change^Genes^ |apoptosome|552.30|APAF1,CASP9| |activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|220.92|APAF1,CASP9| |TORC2 complex|207.11|MAPKAP1,RICTOR,MLST8| |Bcl-2 family protein complex|184.10|BAK1,MCL1,BCL2L11| |TOR signaling|78.90|MAPKAP1,RICTOR,MLST8,LAMTOR4,FLCN| |positive regulation of mitochondrial membrane permeability|59.18|BAK1,VDAC2,BCL2L11| |positive regulation of membrane permeability|53.45|BAK1,VDAC2,BCL2L11| |extrinsic apoptotic signaling pathway in absence of ligand|51.78|BAK1,MCL1,BCL2L11| |signal transduction in absence of ligand|51.78|BAK1,MCL1,BCL2L11| |apoptotic mitochondrial changes|39.45|BAK1,VDAC2,MCL1,BCL2L11| |intrinsic apoptotic signaling pathway in response to DNA damage|31.12|BAK1,MCL1,CASP9,BCL2L11| |intrinsic apoptotic signaling pathway|20.71|BAK1,APAF1,MCL1,CASP9,BCL2L11,FLCN| |regulation of TOR signaling|20.46|RICTOR,MLST8,LAMTOR4,FLCN,MAPKAPK5| |mitochondrial outer membrane|16.01|MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L| |regulation of intrinsic apoptotic signaling pathway|15.96|UBQLN1,VDAC2,MCL1,BCL2L11,FLCN| |organelle outer membrane|14.10|MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L| |outer membrane|13.92|MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L| |apoptotic signaling pathway|12.55|BAK1,VDAC2,APAF1,MCL1,CASP9,BCL2L11,FLCN| |mitochondrial membrane|6.27|MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L,ALAS1,HCCS| </modal> Last modified: 2026/01/15 21:36by 127.0.0.1