VPS25 [The Human Chemical-Genetic Interaction Map Project]

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======= VPS25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS25
  * **<color #00a2e8>Official Name</color>**: vacuolar protein sorting 25 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84313|84313]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRG1|Q9BRG1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610907|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. {ECO:0000269|PubMed:18723511}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ESCRT-II|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ESCRT II complex|
|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|late endosome to vacuole transport via multivesicular body sorting pathway|
|negative regulation of epidermal growth factor-activated receptor activity|
|late endosome to vacuole transport|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|endosome transport via multivesicular body sorting pathway|
|regulation of epidermal growth factor-activated receptor activity|
|negative regulation of protein tyrosine kinase activity|
|multivesicular body assembly|
|multivesicular body organization|
|multivesicular body sorting pathway|
|negative regulation of epidermal growth factor receptor signaling pathway|
|establishment of protein localization to vacuole|
|negative regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of ERBB signaling pathway|
|negative regulation of signaling receptor activity|
|protein localization to vacuole|
|endosome organization|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|protein N-terminus binding|
|vacuolar transport|
|macroautophagy|
|regulation of signaling receptor activity|
|structural molecule activity|
|endosome membrane|
|negative regulation of protein kinase activity|
|endosomal transport|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|autophagy|
|process utilizing autophagic mechanism|
|negative regulation of transferase activity|
|vesicle organization|
|negative regulation of protein phosphorylation|
|endomembrane system organization|
|establishment of protein localization to organelle|
|negative regulation of phosphorylation|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|protein catabolic process|
|protein localization to organelle|
|organelle assembly|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|regulation of transferase activity|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp149|SB203580 25μM R03 exp149]]|-3.77|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-3.6|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-3.16|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-3.16|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-3.05|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-3.03|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-3.01|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.97|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.92|
|[[:results:exp303|39°C R06 exp303]]|-2.91|
|[[:results:exp539|42°C R08 exp539]]|-2.9|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.88|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.87|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.84|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.82|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.8|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.8|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.71|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.71|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-2.71|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-2.67|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.67|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.66|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.65|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.65|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-2.6|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.58|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.56|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.53|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-2.48|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.47|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.47|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.44|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.43|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.43|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.42|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.4|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.37|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.36|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.36|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-2.35|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.35|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.32|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.32|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.31|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.28|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.28|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.26|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.25|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.25|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.24|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.23|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.23|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.23|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.22|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.21|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.16|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.15|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.13|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.13|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.13|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.13|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-2.12|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.11|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2.11|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.09|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.06|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.06|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.06|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-2.05|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.05|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-2.05|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.04|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.02|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-2.02|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.02|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.01|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.01|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.99|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.97|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.97|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.95|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.95|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.94|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.94|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.93|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.93|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.91|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.91|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.91|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.9|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.89|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.86|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.86|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.85|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.84|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.84|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.83|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.83|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.82|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.81|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.81|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.79|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.77|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.77|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.77|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.75|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.74|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.73|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.73|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.73|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.72|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.72|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.72|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.72|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.72|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.72|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.72|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.71|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.7|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.7|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 119
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS25 Expression in NALM6 Cells: 4.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>