∆-9-Tetrahydrocannabinol 30μM R08 exp445 [The Human Chemical-Genetic Interaction Map Project]

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====== ∆-9-Tetrahydrocannabinol 30μM R08 exp445 ======
==== Mechanism of Action ====
Agonist of CB1 and CB2 cannabinoid receptors
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Controlled Substance
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / GPCR Agonist



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Dronabinol%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1972-08-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/16078|16078]]
    * **<color #00a2e8>IUPAC:</color>** %%(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** CYQFCXCEBYINGO-IAGOWNOFSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 314.5
    * **<color #00a2e8>Canonical SMILES:</color>** CCCCCC1=CC(=C2C3C=C(CCC3C(OC2=C1)(C)C)C)O
    * **<color #00a2e8>Isomeric SMILES:</color>** CCCCCC1=CC(=C2[C@@H]3C=C(CC[C@H]3C(OC2=C1)(C)C)C)O
    * **<color #00a2e8>Molecular Formula:</color>** C21H30O2
{{:chemogenomics:structures:chem-0256.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** T293200
    * **<color #00a2e8>Lot #:</color>** 7-YEN-94-6
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C21H30O2 315.23186; found 315.23143
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** THC
    * **<color #00a2e8>Min:</color>** -16.2079; **<color #00a2e8>Max:</color>** 99.4826
{{:chemogenomics:dose_response:dr_627.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |26.9000    |
| IC20  |32.2200    |
| IC30  |36.3200    |
| IC40  |40.0700    |
| IC50  |43.8500    |
| IC60  |47.9900    |
| IC70  |52.9400    |
| IC80  |59.6900    |
| IC90  |71.4800    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 30µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.5
    * **<color #00a2e8>Numbers of reads</color>**: 15258071


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|17/10|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Delta-9-Tetrahydrocannabinol_30uM_Round-8_exp445.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='∆-9-Tetrahydrocannabinol 30μM R08 exp445'>
{{:chemogenomics:cranks_plots:exp445.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:F:FLVCR1|FLVCR1]]|-4.63|<0.01|
|[[:human_genes:C:C1orf43|C1orf43]]|-3.98|<0.01|
|[[:human_genes:E:EPT1|EPT1]]|-3.64|<0.01|
|[[:human_genes:E:ENO1|ENO1]]|-3.45|<0.01|
|[[:human_genes:T:TRAPPC13|TRAPPC13]]|-3.09|<0.01|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-3.07|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-3.06|<0.01|
|[[:human_genes:C:C10orf76|C10orf76]]|-3.01|<0.01|
|[[:human_genes:T:TCF3|TCF3]]|-2.88|0.02|
|[[:human_genes:V:VPS25|VPS25]]|-2.80|0.20|
|[[:human_genes:E:ESPL1|ESPL1]]|-2.75|0.08|
|[[:human_genes:C:CHKA|CHKA]]|-2.75|<0.01|
|[[:human_genes:C:CHMP7|CHMP7]]|-2.71|0.01|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.69|0.01|
|[[:human_genes:O:OSBPL11|OSBPL11]]|-2.66|0.01|
|[[:human_genes:M:MDM2|MDM2]]|-2.66|0.05|
|[[:human_genes:A:ATP2A2|ATP2A2]]|-2.52|0.47|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.47|0.03|
|[[:human_genes:C:C4orf29|C4orf29]]|-2.46|0.03|
|[[:human_genes:E:EP300|EP300]]|-2.46|0.16|
|[[:human_genes:N:NPRL2|NPRL2]]|-2.42|0.11|
|[[:human_genes:D:DMXL1|DMXL1]]|-2.39|0.05|
|[[:human_genes:K:KIAA1109|KIAA1109]]|-2.38|0.05|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-2.35|0.09|
|[[:human_genes:R:RRM2|RRM2]]|-2.35|0.54|
|[[:human_genes:O:OSBPL9|OSBPL9]]|-2.33|0.06|
|[[:human_genes:X:XAB2|XAB2]]|-2.29|0.58|
|[[:human_genes:M:MEF2A|MEF2A]]|-2.28|0.11|
|[[:human_genes:G:GATAD1|GATAD1]]|-2.28|0.16|
|[[:human_genes:U:UBE2A|UBE2A]]|-2.27|0.08|
|[[:human_genes:G:GEMIN7|GEMIN7]]|2.18|0.10|
|[[:human_genes:L:LARS2|LARS2]]|2.20|0.14|
|[[:human_genes:R:RPTOR|RPTOR]]|2.21|0.14|
|[[:human_genes:T:TAZ|TAZ]]|2.21|0.37|
|[[:human_genes:D:DDX1|DDX1]]|2.22|0.09|
|[[:human_genes:D:DDX47|DDX47]]|2.23|0.37|
|[[:human_genes:G:GATAD2B|GATAD2B]]|2.29|0.06|
|[[:human_genes:K:KMT2D|KMT2D]]|2.29|0.06|
|[[:human_genes:E:EIF3H|EIF3H]]|2.31|0.10|
|[[:human_genes:N:NDRG4|NDRG4]]|2.32|0.06|
|[[:human_genes:R:RBM26|RBM26]]|2.33|0.10|
|[[:human_genes:E:EIF4A1|EIF4A1]]|2.35|0.09|
|[[:human_genes:A:ANO5|ANO5]]|2.37|0.05|
|[[:human_genes:E:ETFDH|ETFDH]]|2.37|0.05|
|[[:human_genes:T:TMEM8C|TMEM8C]]|2.38|0.05|
|[[:human_genes:S:SSBP1|SSBP1]]|2.44|0.06|
|[[:human_genes:S:SRM|SRM]]|2.46|0.04|
|[[:human_genes:G:G6PD|G6PD]]|2.46|0.04|
|[[:human_genes:S:SEC62|SEC62]]|2.51|0.05|
|[[:human_genes:B:BAK1|BAK1]]|2.52|0.04|
|[[:human_genes:S:SIN3A|SIN3A]]|2.53|0.05|
|[[:human_genes:S:SLC39A10|SLC39A10]]|2.60|0.04|
|[[:human_genes:R:RNPS1|RNPS1]]|2.68|0.05|
|[[:human_genes:C:CXorf56|CXorf56]]|2.69|0.04|
|[[:human_genes:I:IMPDH2|IMPDH2]]|2.77|0.04|
|[[:human_genes:S:SLC7A1|SLC7A1]]|2.81|0.06|
|[[:human_genes:I:IKZF1|IKZF1]]|3.05|<0.01|
|[[:human_genes:P:PPP6C|PPP6C]]|3.33|<0.01|
|[[:human_genes:P:PTAR1|PTAR1]]|3.34|<0.01|
|[[:human_genes:I:ITPK1|ITPK1]]|5.25|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.08|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp504|MK2206 4μM R08 exp504]]|0.067|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.067|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.067|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|0.065|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.064|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.063|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.063|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.062|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.061|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.06|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.059|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.059|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.058|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|0.057|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|0.053|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|0.053|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|0.052|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.052|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.051|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.051|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.13|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.093|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|0.079|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|0.079|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.078|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.07|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|0.065|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|0.062|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|0.059|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.058|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp275|Citral 75μM R06 exp275]]|0.053|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.052|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.052|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp224|CB-839 10μM R05 exp224]]|0.051|<button type="primary" size="small" modal="35">View</button>|
</modal>


<modal id="1" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp445_vs_exp515.png?nolink |}}
</modal>

<modal id="2" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  MK2206 4μM R08 exp504">
{{:chemogenomics:comparison_plots:exp445_vs_exp504.png?nolink |}}
</modal>

<modal id="3" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp445_vs_exp90.png?nolink |}}
</modal>

<modal id="4" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  FK-506 30μM R07 exp359">
{{:chemogenomics:comparison_plots:exp359_vs_exp445.png?nolink |}}
</modal>

<modal id="5" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Rotenone 0.07μM R08 exp431">
{{:chemogenomics:comparison_plots:exp431_vs_exp445.png?nolink |}}
</modal>

<modal id="6" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp445_vs_exp478.png?nolink |}}
</modal>

<modal id="7" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp445_vs_exp529.png?nolink |}}
</modal>

<modal id="8" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp445_vs_exp488.png?nolink |}}
</modal>

<modal id="9" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp357_vs_exp445.png?nolink |}}
</modal>

<modal id="10" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp445.png?nolink |}}
</modal>

<modal id="11" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp445_vs_exp489.png?nolink |}}
</modal>

<modal id="12" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp445_vs_exp502.png?nolink |}}
</modal>

<modal id="13" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp445_vs_exp85.png?nolink |}}
</modal>

<modal id="14" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp442_vs_exp445.png?nolink |}}
</modal>

<modal id="15" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp445_vs_exp492.png?nolink |}}
</modal>

<modal id="16" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  QNZ 0.01μM R08 exp439">
{{:chemogenomics:comparison_plots:exp439_vs_exp445.png?nolink |}}
</modal>

<modal id="17" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp445_vs_exp79.png?nolink |}}
</modal>

<modal id="18" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp445_vs_exp47.png?nolink |}}
</modal>

<modal id="19" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp445_vs_exp483.png?nolink |}}
</modal>

<modal id="20" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp445_vs_exp525.png?nolink |}}
</modal>

<modal id="21" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp416_vs_exp445.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Cannabidiol 20μM R08 exp466  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp466.png?nolink |}}
</modal>

<modal id="23" size="lg" title="BVD-523 15μM R02 exp67  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp67.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Amiloride 100μM R08 exp447  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp447.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Bisphenol A 100μM R06 exp269  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp269_vs_exp445.png?nolink |}}
</modal>

<modal id="26" size="lg" title="CB-5083 0.4μM R08 exp468  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp468.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp227_vs_exp445.png?nolink |}}
</modal>

<modal id="28" size="lg" title="CAY10603 0.55μM R08 exp467  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp467.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Cannabidiol 13μM R08 exp465  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp465.png?nolink |}}
</modal>

<modal id="30" size="lg" title="Benzoate 10000μM R08 exp455  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp455.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Centrinone 0.5μM R07 exp343  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp343_vs_exp445.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Citral 75μM R06 exp275  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp275_vs_exp445.png?nolink |}}
</modal>

<modal id="33" size="lg" title="BS-181 20μM R08 exp461  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp461.png?nolink |}}
</modal>

<modal id="34" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp344_vs_exp445.png?nolink |}}
</modal>

<modal id="35" size="lg" title="CB-839 10μM R05 exp224  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp224_vs_exp445.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|phosphatidylethanolamine biosynthetic process|220.92|SELENOI,CHKA,CEPT1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>