KIAA1109

Entrez Summary: This gene is located on the long arm of chromosome 4 in a region that is associated with susceptibility to celiac disease. The encoded protein is similar to a Chinese hamster protein that is associated with spermatocyte and adipocyte differentiation. The C-terminus of the protein is also similar to a Caenorhabditis elegans protein that plays a role in lipid storage. In mammals, this protein is thought to function in the regulation of epithelial growth and differentiation, and in tumor development. [provided by RefSeq, Oct 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 1 to 2μM on day4 R04 exp164	-2.48
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.38
BS-181 20μM R08 exp461	-2.2
Trametinib 10μM R02 exp83	-1.72
iCRT14 30μM R08 exp492	-1.71
PF-06409577 20μM R07 exp389	-1.71
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

presynaptic endocytosis
synaptic vesicle endocytosis
synaptic vesicle recycling
presynapse
synaptic vesicle cycle
vesicle-mediated transport in synapse
regulation of epithelial cell differentiation
regulation of cell growth
endocytosis
regulation of growth
import into cell
regulation of cell differentiation
establishment of localization in cell
vesicle-mediated transport
membrane