HDAC7
Gene Information
- Official Symbol: HDAC7
- Official Name: histone deacetylase 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 51564
- UniProt: Q8WUI4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Hist deacetyl |
GO Terms
| NAD-dependent histone deacetylase activity (H3-K14 specific) |
| histone H3 deacetylation |
| positive regulation of cell migration involved in sprouting angiogenesis |
| negative regulation of NIK/NF-kappaB signaling |
| negative regulation of interleukin-2 production |
| 14-3-3 protein binding |
| activating transcription factor binding |
| histone deacetylase complex |
| regulation of cell migration involved in sprouting angiogenesis |
| repressing transcription factor binding |
| positive regulation of sprouting angiogenesis |
| negative regulation of osteoblast differentiation |
| histone deacetylation |
| protein deacetylation |
| protein kinase C binding |
| regulation of interleukin-2 production |
| positive regulation of blood vessel endothelial cell migration |
| protein deacylation |
| macromolecule deacylation |
| vasculogenesis |
| regulation of sprouting angiogenesis |
| negative regulation of ossification |
| regulation of blood vessel endothelial cell migration |
| positive regulation of endothelial cell migration |
| cell-cell junction assembly |
| regulation of NIK/NF-kappaB signaling |
| regulation of osteoblast differentiation |
| cell-cell junction organization |
| positive regulation of epithelial cell migration |
| regulation of endothelial cell migration |
| positive regulation of angiogenesis |
| cell junction assembly |
| positive regulation of vasculature development |
| regulation of ossification |
| cell junction organization |
| regulation of epithelial cell migration |
| transcription corepressor activity |
| negative regulation of cytokine production |
| regulation of angiogenesis |
| regulation of vasculature development |
| histone modification |
| covalent chromatin modification |
| chromatin binding |
| blood vessel morphogenesis |
| protein kinase binding |
| blood vessel development |
| positive regulation of cell migration |
| negative regulation of intracellular signal transduction |
| vasculature development |
| cardiovascular system development |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| tube morphogenesis |
| regulation of cytokine production |
| chromatin organization |
| negative regulation of cell differentiation |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of cell motility |
| negative regulation of developmental process |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of anatomical structure morphogenesis |
| chromosome organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| negative regulation of response to stimulus |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Parthenolide 2.5μM R05 exp238 | 1.77 |
| IU1-C 25μM R04 exp183 | 1.92 |
| Olaparib 4μM R08 exp512 | 1.93 |
| Benzoate 10000μM R08 exp455 | 2.15 |
| Dinaciclib 0.007μM R07 exp355 | 2.31 |
| Staurosporine 0.02μM R08 exp524 | 2.39 |
| Milciclib 2μM R08 exp502 | 3.91 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/25 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13091
- Expression level (log2 read counts): 5.96
Expression Distribution
HDAC7 Expression in NALM6 Cells: 5.96
