PAG1

Official Symbol: PAG1
Official Name: phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Aliases and Previous Symbols: N/A
Entrez ID: 55824
UniProt: Q9NWQ8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 5μM R03 exp102	-3.12
Benzoate 10000μM R08 exp455	-2.9
Sulforaphane 9μM R08 exp526 no dilution day6	-2.89
Torin1 0.08μM R02 exp82	-2.29
Citral 50μM R06 exp274	-2.2
Actinomycin-D 0.01μM R00 exp4	-2.17
CB-5083 0.4μM R08 exp468	-2.14
ML-792 0.2μM R08 exp505	-2.06
UM0131023 0.05μM R05 exp248	-2
B02 10μM R08 exp453	-1.99
MS023 7μM R03 exp135	-1.92
Golgicide-A 4μM R03 exp122	-1.91
Campthothecin 0.001μM R06 exp270	-1.86
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.83
Citral 75μM R06 exp275	-1.81
Sulforaphane 9μM R08 exp525	-1.79
Artemisinin 50μM R08 exp450	-1.78
MS023 2μM R03 exp134	-1.75
Rotenone 0.07μM R08 exp431	-1.71
Pomalidomide 20μM R07 exp391	1.75
GSK-J5 1.5μM R08 exp484	1.82

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SH2 domain binding
SH3/SH2 adaptor activity
negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
negative regulation of lymphocyte activation
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
T cell receptor signaling pathway
negative regulation of cell activation
membrane raft
negative regulation of cell adhesion
antigen receptor-mediated signaling pathway
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
regulation of cell-cell adhesion
negative regulation of immune system process
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
regulation of lymphocyte activation
immune response-activating signal transduction
immune response-regulating signaling pathway
regulation of leukocyte activation
adaptive immune response
activation of immune response
regulation of cell activation
regulation of cell adhesion
positive regulation of immune response
regulation of immune response
positive regulation of immune system process
regulation of immune system process
positive regulation of signal transduction
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling
immune response