SLC1A6

Entrez Summary: N/A
UniProt Summary: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). {ECO:0000250|UniProtKB:O35921, ECO:0000269|PubMed:7791878, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
KU-0063794 3.8μM R02 exp71	-1.82
ETC-159 50μM R08 exp480	2.35

high-affinity glutamate transmembrane transporter activity
L-aspartate transmembrane transporter activity
L-aspartate transmembrane transport
L-glutamate import across plasma membrane
aspartate transmembrane transport
L-glutamate import
amino acid import across plasma membrane
L-glutamate transmembrane transport
amino acid import
C4-dicarboxylate transport
glutamate secretion
neurotransmitter uptake
L-alpha-amino acid transmembrane transport
acidic amino acid transport
intermediate filament cytoskeleton
integral component of presynaptic membrane
L-amino acid transport
drug transmembrane transport
amino acid transmembrane transport
dicarboxylic acid transport
acid secretion
import across plasma membrane
amino acid transport
organic acid transmembrane transport
carboxylic acid transmembrane transport
drug transport
neurotransmitter transport
anion transmembrane transport
organic acid transport
carboxylic acid transport
glutamatergic synapse
regulation of neurotransmitter levels
chemical synaptic transmission
anterograde trans-synaptic signaling
regulation of membrane potential
trans-synaptic signaling
organic anion transport
synaptic signaling
anion transport
import into cell