NOP58

Entrez Summary: N/A
UniProt Summary: Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. {ECO:0000250, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Monensin 0.3μM R08 exp507	-2.18
INK128 0.2μM R02 exp70	-2.08
Q15 1 to 2μM on day4 R04 exp164	-1.73
Calcipotriol 5μM R08 exp464	1.71
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.73
Dihydrosphingosine 8μM R08 exp476	1.79
B02 10μM R08 exp453	1.82
GW501516 25μM R06 exp285	1.84
BI-2536 0.0042μM R03 exp95	1.93
PNU96415E 10μM R03 exp145	1.98
Nicotine 3000μM R08 exp510	2.22
SB203580 25μM R03 exp149	2.46
ETC-159 50μM R08 exp480	2.71

Global Fraction of Cell Lines Where Essential: 720/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	28/28
bone	25/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	19/20
lung	72/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	13/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution

snoRNA localization
box C/D snoRNP complex
pre-snoRNP complex
small nucleolar ribonucleoprotein complex
TFIID-class transcription factor complex binding
snoRNA binding
small-subunit processome
Cajal body
ATPase binding
fibrillar center
rRNA processing
RNA localization
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
membrane
gene expression