NOP58 [The Human Chemical-Genetic Interaction Map Project]

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======= NOP58 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOP58
  * **<color #00a2e8>Official Name</color>**: NOP58 ribonucleoprotein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51602|51602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2X3|Q9Y2X3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOP58&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOP58|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616742|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. {ECO:0000250, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NOP5NT|
|Nop|
|NOSIC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snoRNA localization|
|box C/D snoRNP complex|
|pre-snoRNP complex|
|small nucleolar ribonucleoprotein complex|
|TFIID-class transcription factor complex binding|
|snoRNA binding|
|small-subunit processome|
|Cajal body|
|ATPase binding|
|fibrillar center|
|rRNA processing|
|RNA localization|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.18|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.08|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.73|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.71|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.73|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.79|
|[[:results:exp453|B02 10μM R08 exp453]]|1.82|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.84|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.93|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.98|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.22|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.46|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 720/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|28/28|
|bone|25/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|19/20|
|lung|72/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1259
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOP58 Expression in NALM6 Cells: 7.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>