RAPGEF3

Gene Information

Official Symbol: RAPGEF3
Official Name: Rap guanine nucleotide exchange factor 3
Aliases and Previous Symbols: N/A
Entrez ID: 10411
UniProt: O95398
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14828
Expression level (log2 read counts): 1.05

Expression Distribution

Screen	Score
Vinblastine 0.002μM R01 exp60	-2.23
ETC-159 50μM R08 exp480	-2.19
UMK57 1μM R01 exp59	-1.92
ZLN024 50μM R08 exp538	-1.71

RasGEF
DEP
cNMP binding
RasGEF N

negative regulation of syncytium formation by plasma membrane fusion
Rap guanyl-nucleotide exchange factor activity
Rap protein signal transduction
regulation of histone H3-K9 acetylation
positive regulation of protein export from nucleus
cAMP binding
positive regulation of syncytium formation by plasma membrane fusion
regulation of syncytium formation by plasma membrane fusion
establishment of endothelial barrier
regulation of actin cytoskeleton reorganization
regulation of protein export from nucleus
positive regulation of protein acetylation
endothelial cell development
positive regulation of stress fiber assembly
cortical actin cytoskeleton
cellular response to cAMP
regulation of histone acetylation
positive regulation of actin filament bundle assembly
regulation of peptidyl-lysine acetylation
positive regulation of nucleocytoplasmic transport
microvillus
regulation of protein acetylation
filopodium
endomembrane system
regulation of stress fiber assembly
endothelial cell differentiation
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
endothelium development
response to cAMP
guanyl-nucleotide exchange factor activity
positive regulation of peptidyl-serine phosphorylation
regulation of nucleocytoplasmic transport
response to organophosphorus
regulation of peptidyl-serine phosphorylation
regulation of histone modification
cAMP-mediated signaling
response to purine-containing compound
positive regulation of intracellular protein transport
positive regulation of angiogenesis