SCEL

Entrez Summary: N/A
UniProt Summary: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
IL-3 9ng/ml R08 exp493	-2.49
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.19
Aphidicolin 0.4μM R08 exp440	-2.1
Atovaquone 15μM R08 exp451	-2.1
Geldanamycin 0.01μM R05 exp235	-1.72
Hippuristanol 0.12μM R08 exp488	-1.7
Cisplatin 0.35μM R06 exp273	1.72
TGF-beta1 44ng/ml R08 exp528	1.79
GSK461364A 0.1μM R03 exp126	1.87
Wortmannin 0.5μM R00 exp37	1.95
ETC-159 50μM R08 exp480	2.21

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cornified envelope
positive regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
response to mechanical stimulus
keratinocyte differentiation
regulation of canonical Wnt signaling pathway
epidermal cell differentiation
regulation of Wnt signaling pathway
skin development
epidermis development
embryo development ending in birth or egg hatching
epithelial cell differentiation
perinuclear region of cytoplasm
embryo development
epithelium development
response to abiotic stimulus
positive regulation of signal transduction
tissue development
positive regulation of cell communication
positive regulation of signaling