WDR45
Gene Information
- Official Symbol: WDR45
- Official Name: WD repeat domain 45
- Aliases and Previous Symbols: N/A
- Entrez ID: 11152
- UniProt: Q9Y484
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. {ECO:0000269|PubMed:23435086}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17292
- Expression level (log2 read counts): 4.17
WDR45 Expression in NALM6 Cells: 4.17
