HTR1B [The Human Chemical-Genetic Interaction Map Project]

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======= HTR1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HTR1B
  * **<color #00a2e8>Official Name</color>**: 5-hydroxytryptamine receptor 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3351|3351]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28222|P28222]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HTR1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HTR1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182131|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:15853772, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:8218242}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7TM GPCR Srx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|serotonergic synapse|
|adenylate cyclase-inhibiting serotonin receptor signaling pathway|
|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels|
|negative regulation of serotonin secretion|
|cellular response to temperature stimulus|
|negative regulation of synaptic transmission, GABAergic|
|regulation of serotonin secretion|
|negative regulation of synaptic transmission, glutamatergic|
|drinking behavior|
|serotonin binding|
|G protein-coupled receptor internalization|
|presynaptic modulation of chemical synaptic transmission|
|regulation of presynaptic cytosolic calcium ion concentration|
|desensitization of G protein-coupled receptor signaling pathway|
|negative adaptation of signaling pathway|
|adaptation of signaling pathway|
|negative regulation of neurotransmitter transport|
|calyx of Held|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|vasoconstriction|
|regulation of synaptic transmission, GABAergic|
|response to mineralocorticoid|
|positive regulation of vascular smooth muscle cell proliferation|
|G protein-coupled serotonin receptor signaling pathway|
|neuron cellular homeostasis|
|G protein-coupled serotonin receptor activity|
|cellular response to alkaloid|
|neurotransmitter receptor activity|
|negative regulation of blood vessel diameter|
|serotonin receptor signaling pathway|
|regulation of dopamine secretion|
|bone remodeling|
|negative regulation of G protein-coupled receptor signaling pathway|
|regulation of vascular smooth muscle cell proliferation|
|response to cocaine|
|drug binding|
|integral component of presynaptic membrane|
|negative regulation of synaptic transmission|
|regulation of catecholamine secretion|
|receptor internalization|
|regulation of synaptic transmission, glutamatergic|
|regulation of behavior|
|response to anesthetic|
|regulation of synaptic vesicle exocytosis|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|feeding behavior|
|positive regulation of smooth muscle cell proliferation|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|regulation of amine transport|
|regulation of response to drug|
|tissue remodeling|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|regulation of neurotransmitter secretion|
|receptor metabolic process|
|response to catecholamine|
|response to monoamine|
|response to alkaloid|
|regulation of synaptic vesicle cycle|
|response to ethanol|
|cellular response to ammonium ion|
|regulation of smooth muscle cell proliferation|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|regulation of neurotransmitter transport|
|regulation of G protein-coupled receptor signaling pathway|
|negative regulation of ion transport|
|response to corticosteroid|
|regulation of regulated secretory pathway|
|vascular process in circulatory system|
|response to temperature stimulus|
|response to ammonium ion|
|negative regulation of secretion by cell|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of exocytosis|
|negative regulation of secretion|
|response to alcohol|
|receptor-mediated endocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to steroid hormone|
|regulation of cytosolic calcium ion concentration|
|anatomical structure homeostasis|
|regulation of neurotransmitter levels|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|dendrite|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|regulation of anatomical structure size|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|endocytosis|
|cellular metal ion homeostasis|
|behavior|
|cellular response to organonitrogen compound|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.24|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.81|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.74|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.79|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.82|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.83|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.84|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.9|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.29|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3384
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HTR1B Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>