ALDH4A1

Entrez Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

1-pyrroline-5-carboxylate dehydrogenase activity
proline catabolic process to glutamate
proline catabolic process
4-hydroxyproline catabolic process
glyoxylate metabolic process
proline metabolic process
aldehyde dehydrogenase (NAD) activity
4-hydroxyproline metabolic process
glutamine family amino acid catabolic process
cellular modified amino acid catabolic process
glutamate metabolic process
cellular aldehyde metabolic process
glutamine family amino acid metabolic process
electron transfer activity
dicarboxylic acid metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
electron transport chain
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
cellular amino acid metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
heterocycle catabolic process
small molecule catabolic process
organic cyclic compound catabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
identical protein binding
small molecule metabolic process
organic substance catabolic process
cellular catabolic process