SPOCK1

Official Symbol: SPOCK1
Official Name: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
Aliases and Previous Symbols: N/A
Entrez ID: 6695
UniProt: Q08629
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008].
UniProt Summary: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sarcoplasm
node of Ranvier
metalloendopeptidase inhibitor activity
extracellular matrix binding
cysteine-type endopeptidase inhibitor activity
negative regulation of cell-substrate adhesion
collagen binding
neuromuscular junction
serine-type endopeptidase inhibitor activity
neuron migration
negative regulation of neuron projection development
central nervous system neuron differentiation
negative regulation of cell projection organization
regulation of cell-substrate adhesion
negative regulation of neuron differentiation
negative regulation of endopeptidase activity
postsynaptic density
negative regulation of peptidase activity
negative regulation of cell adhesion
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of cell growth
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of neuron projection development
regulation of neuron differentiation
regulation of growth
regulation of cell adhesion
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
calcium ion binding
regulation of proteolysis
negative regulation of catalytic activity
regulation of neurogenesis
regulation of nervous system development