TMEM203

Entrez Summary: N/A
UniProt Summary: Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873). {ECO:0000269|PubMed:25996873}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.97
Trimetrexate 0.03μM R08 exp535	-2.02
RK-33 8μM R08 exp518	1.8
Arsenate 40μM R06 exp264	2.51

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
spermatogenesis
cellular metal ion homeostasis
male gamete generation
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
gamete generation
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
cellular homeostasis
endoplasmic reticulum membrane
multi-organism reproductive process
endoplasmic reticulum
chemical homeostasis
reproductive process
reproduction
homeostatic process