GABRB1

Entrez Summary: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269|PubMed:26950270}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rifampicin 30μM R08 exp430	-2.03
Thalidomide 20μM R07 exp406	-1.74
Etoposide 0.3μM R05 exp199	-1.73
CFI-400945 25μM R08 exp469	1.72
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.44

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Neur chan LBD
Neur chan memb

cellular response to histamine
response to histamine
ligand-gated ion channel activity
GABA-gated chloride ion channel activity
GABA receptor binding
GABA-A receptor activity
GABA-A receptor complex
gamma-aminobutyric acid signaling pathway
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
response to progesterone
chloride channel complex
extracellular ligand-gated ion channel activity
GABA-ergic synapse
ovulation cycle
central nervous system neuron development
chloride transmembrane transport
regulation of postsynaptic membrane potential
chloride transport
inorganic anion transmembrane transport
cellular response to ammonium ion
inorganic anion transport
central nervous system neuron differentiation
nuclear envelope
response to ammonium ion
response to ketone
postsynaptic membrane
synapse
rhythmic process
anion transmembrane transport
neuron projection
response to steroid hormone
dendrite
chemical synaptic transmission
anterograde trans-synaptic signaling
regulation of membrane potential
trans-synaptic signaling
synaptic signaling
response to toxic substance
cellular response to organic cyclic compound
cell junction