ICMT

Entrez Summary: N/A
UniProt Summary: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 1μM R00 exp29	-1.89
LY2090314 0.003μM R08 exp499	-1.87
Taxol 0.002μM R01 exp54	-1.81
Ethanol 0.01 R05 exp234	-1.74
Momordin-Ic 10μM R08 exp506	-1.74
Wortmannin 0.5μM R00 exp37	-1.73
DABN racemic mixture R03 exp93	1.91
Bafilomycin-A1 0.009μM R08 exp454	2.29
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	3.48

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
C-terminal protein methylation
protein C-terminal carboxyl O-methyltransferase activity
C-terminal protein amino acid modification
protein alkylation
protein methylation
protein targeting to membrane
macromolecule methylation
establishment of protein localization to membrane
methylation
protein targeting
post-translational protein modification
protein localization to membrane
endoplasmic reticulum membrane
intracellular protein transport
endoplasmic reticulum
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
membrane