TBCA [The Human Chemical-Genetic Interaction Map Project]

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======= TBCA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBCA
  * **<color #00a2e8>Official Name</color>**: tubulin folding cofactor A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6902|6902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75347|O75347]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBCA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBCA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610058|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBCA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-chaperonin tubulin folding pathway|
|tubulin complex assembly|
|beta-tubulin binding|
|tubulin binding|
|chaperone binding|
|microtubule cytoskeleton|
|protein folding|
|microtubule|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.15|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.11|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-2.09|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.93|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.86|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.82|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.81|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.75|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.75|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.71|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.9|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dpagt1|DPAGT1]]|0.571|
|[[:human genes:t:thg1l|THG1L]]|0.563|
|[[:human genes:h:hars|HARS]]|0.56|
|[[:human genes:p:pmm2|PMM2]]|0.557|
|[[:human genes:g:gmppb|GMPPB]]|0.544|
|[[:human genes:u:uap1|UAP1]]|0.536|
|[[:human genes:r:rtcb|RTCB]]|0.532|
|[[:human genes:g:gfpt1|GFPT1]]|0.531|
|[[:human genes:a:atxn10|ATXN10]]|0.527|
|[[:human genes:n:nsmce1|NSMCE1]]|0.521|
|[[:human genes:t:triap1|TRIAP1]]|0.514|
|[[:human genes:r:rnmt|RNMT]]|0.507|
|[[:human genes:g:gemin8|GEMIN8]]|0.507|
|[[:human genes:m:mars|MARS]]|0.502|
|[[:human genes:f:fnta|FNTA]]|0.501|
|[[:human genes:u:utp23|UTP23]]|0.5|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.494|
|[[:human genes:s:srp14|SRP14]]|0.494|
|[[:human genes:r:rbm14|RBM14]]|0.492|
|[[:human genes:e:eprs|EPRS]]|0.49|
|[[:human genes:a:alg1|ALG1]]|0.487|
|[[:human genes:t:tti2|TTI2]]|0.485|
|[[:human genes:h:hspd1|HSPD1]]|0.477|
|[[:human genes:a:alg13|ALG13]]|0.475|
|[[:human genes:e:eno1|ENO1]]|0.474|
|[[:human genes:d:dhps|DHPS]]|0.473|
|[[:human genes:d:dohh|DOHH]]|0.472|
|[[:human genes:a:adsl|ADSL]]|0.468|
|[[:human genes:h:haus8|HAUS8]]|0.467|
|[[:human genes:d:ddx20|DDX20]]|0.467|
|[[:human genes:v:vrk1|VRK1]]|0.464|
|[[:human genes:g:gnb1l|GNB1L]]|0.463|
|[[:human genes:r:rpe|RPE]]|0.463|
|[[:human genes:n:nae1|NAE1]]|0.461|
|[[:human genes:p:pelo|PELO]]|0.461|
|[[:human genes:t:tbcd|TBCD]]|0.461|
|[[:human genes:d:ddx55|DDX55]]|0.459|
|[[:human genes:v:vezt|VEZT]]|0.456|
|[[:human genes:a:alg14|ALG14]]|0.456|
|[[:human genes:d:dhdds|DHDDS]]|0.456|
|[[:human genes:o:oraov1|ORAOV1]]|0.454|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.45|
|[[:human genes:t:tsen34|TSEN34]]|0.45|
|[[:human genes:g:gtf3a|GTF3A]]|0.449|
|[[:human genes:r:rad1|RAD1]]|0.448|
|[[:human genes:o:oip5|OIP5]]|0.447|
|[[:human genes:h:hccs|HCCS]]|0.447|
|[[:human genes:p:ppp4c|PPP4C]]|0.445|
|[[:human genes:n:nars|NARS]]|0.445|
|[[:human genes:r:rptor|RPTOR]]|0.444|
|[[:human genes:t:timm13|TIMM13]]|0.442|
|[[:human genes:t:tsen54|TSEN54]]|0.442|
|[[:human genes:s:srp68|SRP68]]|0.442|
|[[:human genes:u:uhrf1|UHRF1]]|0.441|
|[[:human genes:t:tprkb|TPRKB]]|0.44|
|[[:human genes:a:alg2|ALG2]]|0.44|
|[[:human genes:t:tgs1|TGS1]]|0.438|
|[[:human genes:m:meaf6|MEAF6]]|0.437|
|[[:human genes:a:aars|AARS]]|0.435|
|[[:human genes:s:srp72|SRP72]]|0.435|
|[[:human genes:p:polr3h|POLR3H]]|0.435|
|[[:human genes:a:actr10|ACTR10]]|0.433|
|[[:human genes:c:csnk2b|CSNK2B]]|0.432|
|[[:human genes:z:zrsr2|ZRSR2]]|0.43|
|[[:human genes:d:dad1|DAD1]]|0.428|
|[[:human genes:a:alg5|ALG5]]|0.427|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.427|
|[[:human genes:p:ppa2|PPA2]]|0.426|
|[[:human genes:t:tamm41|TAMM41]]|0.425|
|[[:human genes:p:polr3b|POLR3B]]|0.424|
|[[:human genes:g:gemin6|GEMIN6]]|0.422|
|[[:human genes:t:taz|TAZ]]|0.421|
|[[:human genes:o:osgep|OSGEP]]|0.421|
|[[:human genes:p:pam16|PAM16]]|0.42|
|[[:human genes:c:crls1|CRLS1]]|0.42|
|[[:human genes:o:orc5|ORC5]]|0.42|
|[[:human genes:t:txnl4b|TXNL4B]]|0.419|
|[[:human genes:r:rpp21|RPP21]]|0.418|
|[[:human genes:e:eny2|ENY2]]|0.417|
|[[:human genes:z:znf259|ZNF259]]|0.416|
|[[:human genes:d:dctn6|DCTN6]]|0.414|
|[[:human genes:e:eif4e|EIF4E]]|0.414|
|[[:human genes:e:eif3f|EIF3F]]|0.414|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.413|
|[[:human genes:c:crcp|CRCP]]|0.412|
|[[:human genes:k:kntc1|KNTC1]]|0.411|
|[[:human genes:t:trmt5|TRMT5]]|0.411|
|[[:human genes:e:exoc4|EXOC4]]|0.411|
|[[:human genes:g:gemin5|GEMIN5]]|0.41|
|[[:human genes:a:apaf1|APAF1]]|0.41|
|[[:human genes:c:ctc1|CTC1]]|0.41|
|[[:human genes:u:uxt|UXT]]|0.409|
|[[:human genes:m:mad2l1|MAD2L1]]|0.406|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.406|
|[[:human genes:b:bub3|BUB3]]|0.406|
|[[:human genes:y:yars|YARS]]|0.405|
|[[:human genes:g:gfer|GFER]]|0.405|
|[[:human genes:c:cct7|CCT7]]|0.404|
|[[:human genes:c:c14orf80|C14orf80]]|0.403|
|[[:human genes:e:exoc3|EXOC3]]|0.403|
|[[:human genes:c:ccdc101|CCDC101]]|0.402|
|[[:human genes:t:trnt1|TRNT1]]|0.402|
|[[:human genes:p:ppcs|PPCS]]|0.401|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.401|
|[[:human genes:p:pmpcb|PMPCB]]|0.4|
|[[:human genes:s:srp19|SRP19]]|0.4|
|[[:human genes:m:mtor|MTOR]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 244/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|9/28|
|bone|11/26|
|breast|13/33|
|central nervous system|12/56|
|cervix|2/4|
|colorectal|2/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|4/21|
|liver|8/20|
|lung|29/75|
|lymphocyte|5/16|
|ovary|6/26|
|pancreas|12/24|
|peripheral nervous system|8/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|8/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1350
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBCA Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>