POLK

Entrez Summary: This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

site of DNA damage
error-prone translesion synthesis
nucleotide-excision repair, DNA gap filling
DNA-directed DNA polymerase activity
nucleotide-excision repair, DNA incision, 5-to lesion
nucleotide-excision repair, DNA incision
translesion synthesis
DNA synthesis involved in DNA repair
postreplication repair
damaged DNA binding
transcription-coupled nucleotide-excision repair
cellular response to UV
DNA biosynthetic process
nucleotide-excision repair
cellular response to light stimulus
response to UV
cellular response to radiation
DNA replication
nuclear body
nucleic acid phosphodiester bond hydrolysis
response to light stimulus
cellular response to abiotic stimulus
cellular response to environmental stimulus
response to radiation
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
nucleobase-containing compound biosynthetic process
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process