DHX33 [The Human Chemical-Genetic Interaction Map Project]

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======= DHX33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHX33
  * **<color #00a2e8>Official Name</color>**: DEAH-box helicase 33
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56919|56919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6R0|Q9H6R0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHX33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHX33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614405|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization. {ECO:0000269|PubMed:21930779}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|HA2|
|OB NTP bind|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rDNA binding|
|positive regulation of NLRP3 inflammasome complex assembly|
|NLRP3 inflammasome complex|
|ribosomal large subunit binding|
|regulation of NLRP3 inflammasome complex assembly|
|3-5 RNA helicase activity|
|positive regulation of transcription by RNA polymerase I|
|regulation of transcription by RNA polymerase I|
|activating transcription factor binding|
|double-stranded RNA binding|
|positive regulation of type I interferon production|
|regulation of type I interferon production|
|translational initiation|
|positive regulation of NF-kappaB transcription factor activity|
|mRNA binding|
|positive regulation of protein complex assembly|
|positive regulation of DNA-binding transcription factor activity|
|translation|
|peptide biosynthetic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|positive regulation of cellular component biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|positive regulation of MAPK cascade|
|regulation of cytokine production|
|regulation of MAPK cascade|
|cellular amide metabolic process|
|nucleolus|
|regulation of cellular component biogenesis|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.42|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.32|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.14|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.11|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.1|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.93|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.86|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.86|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.75|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.458|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 696/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/26|
|breast|27/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|20/20|
|lung|71/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|12/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 286
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHX33 Expression in NALM6 Cells: 7.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>