KDSR [The Human Chemical-Genetic Interaction Map Project]

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======= KDSR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KDSR
  * **<color #00a2e8>Official Name</color>**: 3-ketodihydrosphingosine reductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2531|2531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06136|Q06136]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KDSR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KDSR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). {ECO:0000269|PubMed:28575652}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KR|
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-dehydrosphinganine reductase activity|
|3-keto-sphinganine metabolic process|
|sphingoid metabolic process|
|cellular ketone metabolic process|
|sphingolipid biosynthetic process|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|ammonium ion metabolic process|
|membrane lipid metabolic process|
|lipid biosynthetic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|endoplasmic reticulum|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|extracellular space|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp149|SB203580 25μM R03 exp149]]|-4.78|
|[[:results:exp169|BH1 1μM R04 exp169]]|-4.68|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-4.49|
|[[:results:exp453|B02 10μM R08 exp453]]|-4.32|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-3.84|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-3.66|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-3.62|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-3.6|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-3.59|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-3.57|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-3.54|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-3.47|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-3.47|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-3.42|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-3.38|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-3.37|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.33|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-3.27|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-3.24|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-3.17|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-3.17|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-3.13|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-3.07|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.07|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-3.04|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2.98|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.84|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.84|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.77|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.72|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.7|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.65|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.65|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.61|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.61|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.6|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-2.59|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.58|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.55|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-2.54|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.51|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-2.47|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.46|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.39|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.35|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.35|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.34|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.33|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-2.33|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.3|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.29|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.25|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.21|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.19|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.19|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.19|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-2.18|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.18|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.16|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-2.15|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-2.14|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.14|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.14|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.13|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.11|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.1|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.09|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.06|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.05|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.01|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.99|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.97|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.91|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.88|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.83|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.77|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.75|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.75|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.73|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.72|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.72|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.72|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.71|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.74|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.8|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.82|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.85|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.85|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.85|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.9|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.96|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.97|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.03|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.05|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.13|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.14|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.21|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.27|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.28|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.3|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.31|
|[[:results:exp135|MS023 7μM R03 exp135]]|4.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.609|
|[[:human genes:d:dhrsx|DHRSX]]|0.588|
|[[:human genes:d:dohh|DOHH]]|0.577|
|[[:human genes:f:faf2|FAF2]]|0.558|
|[[:human genes:r:romo1|ROMO1]]|0.557|
|[[:human genes:d:dolk|DOLK]]|0.548|
|[[:human genes:p:plaa|PLAA]]|0.542|
|[[:human genes:t:triap1|TRIAP1]]|0.529|
|[[:human genes:t:trmt61a|TRMT61A]]|0.524|
|[[:human genes:e:elp3|ELP3]]|0.524|
|[[:human genes:p:pgm3|PGM3]]|0.522|
|[[:human genes:c:cept1|CEPT1]]|0.52|
|[[:human genes:s:ssb|SSB]]|0.52|
|[[:human genes:a:alg1|ALG1]]|0.515|
|[[:human genes:g:gfpt1|GFPT1]]|0.507|
|[[:human genes:p:ppa2|PPA2]]|0.505|
|[[:human genes:r:rptor|RPTOR]]|0.503|
|[[:human genes:v:vezt|VEZT]]|0.502|
|[[:human genes:u:ube2g2|UBE2G2]]|0.5|
|[[:human genes:d:dnlz|DNLZ]]|0.499|
|[[:human genes:s:srp14|SRP14]]|0.498|
|[[:human genes:a:apaf1|APAF1]]|0.497|
|[[:human genes:s:sec62|SEC62]]|0.497|
|[[:human genes:a:alg6|ALG6]]|0.495|
|[[:human genes:m:mbtps1|MBTPS1]]|0.495|
|[[:human genes:b:bak1|BAK1]]|0.494|
|[[:human genes:m:mocs3|MOCS3]]|0.493|
|[[:human genes:f:flvcr1|FLVCR1]]|0.493|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.488|
|[[:human genes:a:atp5o|ATP5O]]|0.479|
|[[:human genes:u:uap1|UAP1]]|0.477|
|[[:human genes:d:dpagt1|DPAGT1]]|0.477|
|[[:human genes:e:eny2|ENY2]]|0.475|
|[[:human genes:t:trmt10a|TRMT10A]]|0.475|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.474|
|[[:human genes:e:elp2|ELP2]]|0.473|
|[[:human genes:r:rnmt|RNMT]]|0.472|
|[[:human genes:s:serf2|SERF2]]|0.472|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.471|
|[[:human genes:s:slc25a26|SLC25A26]]|0.471|
|[[:human genes:s:srd5a3|SRD5A3]]|0.471|
|[[:human genes:y:yars2|YARS2]]|0.469|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.468|
|[[:human genes:a:atic|ATIC]]|0.467|
|[[:human genes:a:atp2a2|ATP2A2]]|0.466|
|[[:human genes:a:atp5j|ATP5J]]|0.465|
|[[:human genes:n:nsd1|NSD1]]|0.463|
|[[:human genes:r:rft1|RFT1]]|0.458|
|[[:human genes:u:urm1|URM1]]|0.458|
|[[:human genes:b:bcs1l|BCS1L]]|0.456|
|[[:human genes:p:pik3r4|PIK3R4]]|0.453|
|[[:human genes:a:atp5a1|ATP5A1]]|0.453|
|[[:human genes:f:fh|FH]]|0.451|
|[[:human genes:h:hccs|HCCS]]|0.45|
|[[:human genes:c:casp9|CASP9]]|0.45|
|[[:human genes:p:pik3c3|PIK3C3]]|0.449|
|[[:human genes:p:pmm2|PMM2]]|0.449|
|[[:human genes:c:chka|CHKA]]|0.448|
|[[:human genes:n:n6amt1|N6AMT1]]|0.447|
|[[:human genes:g:gmppb|GMPPB]]|0.445|
|[[:human genes:a:atxn10|ATXN10]]|0.445|
|[[:human genes:t:tamm41|TAMM41]]|0.443|
|[[:human genes:m:mlst8|MLST8]]|0.442|
|[[:human genes:v:vdac2|VDAC2]]|0.44|
|[[:human genes:a:atp5b|ATP5B]]|0.44|
|[[:human genes:d:dars2|DARS2]]|0.439|
|[[:human genes:e:exoc4|EXOC4]]|0.438|
|[[:human genes:a:alg13|ALG13]]|0.435|
|[[:human genes:m:mbtps2|MBTPS2]]|0.435|
|[[:human genes:p:pdap1|PDAP1]]|0.434|
|[[:human genes:u:ubqln1|UBQLN1]]|0.434|
|[[:human genes:e:elp6|ELP6]]|0.433|
|[[:human genes:t:timm22|TIMM22]]|0.431|
|[[:human genes:a:atp5i|ATP5I]]|0.43|
|[[:human genes:l:lsm10|LSM10]]|0.43|
|[[:human genes:s:srrd|SRRD]]|0.43|
|[[:human genes:c:crls1|CRLS1]]|0.428|
|[[:human genes:c:cbfb|CBFB]]|0.427|
|[[:human genes:d:dr1|DR1]]|0.427|
|[[:human genes:a:alg5|ALG5]]|0.427|
|[[:human genes:c:c10orf2|C10orf2]]|0.425|
|[[:human genes:b:bap1|BAP1]]|0.424|
|[[:human genes:t:ten1|TEN1]]|0.423|
|[[:human genes:a:atp5d|ATP5D]]|0.423|
|[[:human genes:v:vps41|VPS41]]|0.422|
|[[:human genes:p:ppcdc|PPCDC]]|0.422|
|[[:human genes:p:pars2|PARS2]]|0.422|
|[[:human genes:c:ctu1|CTU1]]|0.422|
|[[:human genes:t:tsen54|TSEN54]]|0.421|
|[[:human genes:m:march5|MARCH5]]|0.421|
|[[:human genes:p:ptdss1|PTDSS1]]|0.42|
|[[:human genes:p:pmvk|PMVK]]|0.418|
|[[:human genes:t:tefm|TEFM]]|0.418|
|[[:human genes:r:rpia|RPIA]]|0.417|
|[[:human genes:d:dusp12|DUSP12]]|0.417|
|[[:human genes:h:hspd1|HSPD1]]|0.416|
|[[:human genes:c:cycs|CYCS]]|0.415|
|[[:human genes:r:rpp21|RPP21]]|0.414|
|[[:human genes:m:mrps14|MRPS14]]|0.414|
|[[:human genes:f:fech|FECH]]|0.413|
|[[:human genes:p:pgs1|PGS1]]|0.413|
|[[:human genes:z:zzz3|ZZZ3]]|0.413|
|[[:human genes:b:bptf|BPTF]]|0.413|
|[[:human genes:n:ncor1|NCOR1]]|0.412|
|[[:human genes:m:mtor|MTOR]]|0.411|
|[[:human genes:k:kiaa1432|KIAA1432]]|0.41|
|[[:human genes:s:spr|SPR]]|0.41|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.41|
|[[:human genes:m:mrpl21|MRPL21]]|0.41|
|[[:human genes:c:chchd4|CHCHD4]]|0.409|
|[[:human genes:a:alg9|ALG9]]|0.409|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.408|
|[[:human genes:a:atp5l|ATP5L]]|0.408|
|[[:human genes:t:trnt1|TRNT1]]|0.408|
|[[:human genes:c:cnep1r1|CNEP1R1]]|0.407|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.407|
|[[:human genes:h:h2afz|H2AFZ]]|0.404|
|[[:human genes:w:wdr24|WDR24]]|0.401|
|[[:human genes:t:taz|TAZ]]|0.401|
|[[:human genes:d:dph5|DPH5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 33/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7669
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KDSR Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>