NEK5

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Resveratrol 16μM R03 exp147	-2.29
IWR1 50μM R08 exp495	1.99

Gene	Correlation
HGC6.3	0.579
POLR2J3	0.468

Pkinase Tyr
Pkinase

positive regulation of striated muscle cell differentiation
positive regulation of muscle cell differentiation
regulation of striated muscle cell differentiation
positive regulation of cysteine-type endopeptidase activity
regulation of muscle cell differentiation
positive regulation of endopeptidase activity
positive regulation of peptidase activity
regulation of cysteine-type endopeptidase activity
positive regulation of proteolysis
protein serine/threonine kinase activity
regulation of endopeptidase activity
regulation of peptidase activity
regulation of proteolysis
positive regulation of hydrolase activity
positive regulation of cell differentiation
protein phosphorylation
regulation of hydrolase activity
phosphorylation
positive regulation of developmental process
positive regulation of catalytic activity
ATP binding
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of cell differentiation