YWHAE
Gene Information
- Official Symbol: YWHAE
- Official Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
- Aliases and Previous Symbols: N/A
- Entrez ID: 7531
- UniProt: P62258
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| 14-3-3 |
GO Terms
| negative regulation of calcium ion export across plasma membrane |
| regulation of heart rate by hormone |
| regulation of calcium ion export across plasma membrane |
| negative regulation of peptidyl-serine dephosphorylation |
| phosphoserine residue binding |
| central region of growth cone |
| regulation of peptidyl-serine dephosphorylation |
| regulation of heart rate by chemical signal |
| MHC class II protein complex binding |
| cardiac muscle cell membrane repolarization |
| membrane repolarization during action potential |
| membrane repolarization during cardiac muscle cell action potential |
| positive regulation of protein export from nucleus |
| membrane repolarization |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| hippo signaling |
| regulation of membrane repolarization |
| phosphoprotein binding |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| negative regulation of calcium ion transmembrane transporter activity |
| calcium channel regulator activity |
| regulation of heart rate by cardiac conduction |
| regulation of protein export from nucleus |
| negative regulation of calcium ion transmembrane transport |
| potassium channel regulator activity |
| substantia nigra development |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| regulation of postsynaptic membrane neurotransmitter receptor levels |
| cardiac muscle cell action potential |
| kinesin complex |
| regulation of potassium ion transmembrane transporter activity |
| positive regulation of establishment of protein localization to mitochondrion |
| scaffold protein binding |
| negative regulation of calcium ion transport |
| neural nucleus development |
| positive regulation of nucleocytoplasmic transport |
| negative regulation of protein dephosphorylation |
| cellular response to heat |
| negative regulation of ion transmembrane transporter activity |
| regulation of mitochondrial membrane permeability |
| regulation of establishment of protein localization to mitochondrion |
| negative regulation of transporter activity |
| regulation of cellular response to heat |
| regulation of potassium ion transmembrane transport |
| regulation of membrane permeability |
| hippocampus development |
| negative regulation of cation transmembrane transport |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| midbrain development |
| regulation of calcium ion transmembrane transporter activity |
| negative regulation of cysteine-type endopeptidase activity |
| cardiac conduction |
| action potential |
| regulation of potassium ion transport |
| ciliary basal body-plasma membrane docking |
| negative regulation of ion transmembrane transport |
| regulation of heart rate |
| melanosome |
| regulation of nucleocytoplasmic transport |
| response to heat |
| limbic system development |
| negative regulation of dephosphorylation |
| histone deacetylase binding |
| positive regulation of mitochondrion organization |
| negative regulation of transmembrane transport |
| cerebral cortex development |
| neuron migration |
| positive regulation of protein localization to membrane |
| ion channel binding |
| mitochondrial membrane organization |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| multicellular organismal signaling |
| regulation of protein dephosphorylation |
| negative regulation of ion transport |
| regulation of calcium ion transmembrane transport |
| positive regulation of intracellular protein transport |
| protein localization to nucleus |
| organelle localization by membrane tethering |
| pallium development |
| positive regulation of apoptotic signaling pathway |
| response to temperature stimulus |
| membrane docking |
| regulation of mitochondrion organization |
| regulation of protein localization to membrane |
| regulation of G2/M transition of mitotic cell cycle |
| positive regulation of intracellular transport |
| regulation of dephosphorylation |
| regulation of cell cycle G2/M phase transition |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| mitochondrial transport |
| regulation of intracellular protein transport |
| regulation of cysteine-type endopeptidase activity |
| regulation of heart contraction |
| negative regulation of endopeptidase activity |
| protein domain specific binding |
| regulation of calcium ion transport |
| negative regulation of peptidase activity |
| regulation of ion transmembrane transporter activity |
| telencephalon development |
| regulation of transmembrane transporter activity |
| mitotic cell cycle phase transition |
| regulation of transporter activity |
| cell cycle phase transition |
| regulation of blood circulation |
| ubiquitin protein ligase binding |
| cadherin binding |
| positive regulation of cellular protein localization |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| cilium assembly |
| glutamatergic synapse |
| enzyme binding |
| regulation of intracellular transport |
| negative regulation of proteolysis |
| protein targeting |
| cilium organization |
| MAPK cascade |
| forebrain development |
| regulation of metal ion transport |
| signal transduction by protein phosphorylation |
| regulation of apoptotic signaling pathway |
| regulation of mitotic cell cycle phase transition |
| focal adhesion |
| regulation of endopeptidase activity |
| positive regulation of protein transport |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| mitochondrion organization |
| regulation of peptidase activity |
| plasma membrane bounded cell projection assembly |
| regulation of cell cycle phase transition |
| calcium ion homeostasis |
| negative regulation of hydrolase activity |
| cell projection assembly |
| positive regulation of establishment of protein localization |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| regulation of cellular protein localization |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| organelle localization |
| regulation of system process |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| metal ion homeostasis |
| regulation of mitotic cell cycle |
| cellular cation homeostasis |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| mitotic cell cycle |
| positive regulation of cell death |
| regulation of ion transport |
| viral process |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| regulation of proteolysis |
| regulation of cellular response to stress |
| protein localization to organelle |
| regulation of peptide transport |
| brain development |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of cell cycle process |
| organelle assembly |
| head development |
| symbiotic process |
| ion homeostasis |
| negative regulation of catalytic activity |
| interspecies interaction between organisms |
| membrane organization |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| ion transmembrane transport |
| cell migration |
| protein phosphorylation |
| central nervous system development |
| positive regulation of transport |
| negative regulation of cell death |
| intracellular protein transport |
| cell cycle process |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| identical protein binding |
| localization of cell |
| cell motility |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| response to abiotic stimulus |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| mitochondrion |
| transmembrane transport |
| regulation of hydrolase activity |
| phosphorylation |
| regulation of organelle organization |
| locomotion |
| cell cycle |
| ion transport |
| RNA binding |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6568
- Expression level (log2 read counts): 8.61
Expression Distribution
YWHAE Expression in NALM6 Cells: 8.61
