PNISR [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: PNISR
Official Name: PNN interacting serine and arginine rich protein
Aliases and Previous Symbols: N/A
Entrez ID: 25957
UniProt: Q8TF01
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.74
Tozasertib 0.1μM R07 exp414	1.81
Actinomycin-D 0.001μM R00 exp3	1.9
Olaparib 4μM R08 exp512	2.01
Cytochalasin-B 5μM R07 exp349	2.13
Resveratrol 16μM R03 exp147	2.18
5-Fluorouracil 20μM R00 exp2	2.19
Diepoxybutane 3μM R07 exp354	2.56
Aminopterin 0.005μM R07 exp335	2.6

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1088
Expression level (log2 read counts): 8.52

Expression Distribution

Last modified: 2025/12/10 20:19
by 127.0.0.1