DLG3

• Official Symbol: DLG3
• Official Name: discs large MAGUK scaffold protein 3
• Aliases and Previous Symbols: N/A
• Entrez ID: 1741
• UniProt: Q92796
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009].
• UniProt Summary: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 16204
• Expression level (log2 read counts): 4.42

Expression Distribution

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DLG3 Expression in NALM6 Cells: 4.42