ISCA1

Entrez Summary: N/A
UniProt Summary: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269|PubMed:15262227, ECO:0000269|PubMed:22323289}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 1μM R01 exp51	-2.38
Parthenolide 2.5μM R05 exp238	-1.78
GSK461364A 0.005μM R03 exp125	1.73
Deferoxamine 11μM R07 exp350	1.79
Atovaquone 15μM R08 exp451	1.93
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein maturation by iron-sulfur cluster transfer
metallo-sulfur cluster assembly
iron-sulfur cluster assembly
2 iron, 2 sulfur cluster binding
structural molecule activity
cofactor biosynthetic process
protein maturation
sulfur compound metabolic process
mitochondrial matrix
cofactor metabolic process
mitochondrion
small molecule metabolic process
gene expression