UBASH3B

Entrez Summary: N/A
UniProt Summary: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17880946}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

collagen-activated tyrosine kinase receptor signaling pathway
negative regulation of platelet aggregation
collagen-activated signaling pathway
negative regulation of bone resorption
negative regulation of homotypic cell-cell adhesion
negative regulation of bone remodeling
regulation of platelet aggregation
negative regulation of platelet activation
negative regulation of tissue remodeling
regulation of homotypic cell-cell adhesion
negative regulation of osteoclast differentiation
regulation of platelet activation
phosphoprotein binding
regulation of bone resorption
platelet aggregation
negative regulation of myeloid leukocyte differentiation
phosphatase activity
regulation of bone remodeling
negative regulation of blood coagulation
negative regulation of hemostasis
negative regulation of coagulation
homotypic cell-cell adhesion
regulation of osteoclast differentiation
negative regulation of wound healing
regulation of tissue remodeling
negative regulation of myeloid cell differentiation
regulation of release of sequestered calcium ion into cytosol
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
negative regulation of response to wounding
regulation of calcium ion transport into cytosol
protein tyrosine phosphatase activity
negative regulation of leukocyte differentiation
peptidyl-tyrosine dephosphorylation
regulation of myeloid leukocyte differentiation
regulation of sequestering of calcium ion
negative regulation of hemopoiesis
platelet activation
regulation of wound healing