MFGE8

Gene Information
  • Official Symbol: MFGE8
  • Official Name: milk fat globule EGF and factor V/VIII domain containing
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 4240
  • UniProt: Q08431
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. {ECO:0000250, ECO:0000269|PubMed:19204935}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 3114
  • Expression level (log2 read counts): 5.7

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1