SWI5

Entrez Summary: N/A
UniProt Summary: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. {ECO:0000269|PubMed:21252223}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rucaparib 6.5μM R08 exp520	-2.75
Campthothecin 0.001μM R06 exp270	-2.72
Menadione 5μM R06 exp292	-2.56
Etoposide 0.1μM R05 exp198	-2.55
Pyridostatin 4μM R05 exp240	-2.54
Bisphenol S 100μM R08 exp458	-2.51
Olaparib 4μM R08 exp512	-2.43
Genistein 15μM R07 exp360	-2.36
CCT251545 20μM R07 exp326	-2.27
UM0131023 0.05μM R05 exp248	-2.15
Dorsomorphin 5μM R07 exp357	-2.09
Rotenone 0.07μM R08 exp431	-2.08
Diepoxybutane 3μM R07 exp354	-2
5-Fluorouracil 2μM R00 exp1	-1.9
CAY10603 0.55μM R08 exp467	-1.86
ABT-702 5μM R06 exp261	-1.85
UM0011500 10μM R05 exp246	-1.84
BML-284 0.09μM R08 exp460	-1.81
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.78
CR131-b 0.005μM R08 exp474	-1.77
CCCP 0.1μM R00 exp10	-1.73
Talazoparib 0.006μM R06 exp299	-1.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Swi5-Sfr1 complex
DNA recombinase assembly
DNA repair complex assembly
double-strand break repair via synthesis-dependent strand annealing
cellular response to ionizing radiation
double-strand break repair via homologous recombination
recombinational repair
response to ionizing radiation
cellular response to radiation
double-strand break repair
protein-DNA complex assembly
DNA recombination
protein-DNA complex subunit organization
cellular response to abiotic stimulus
cellular response to environmental stimulus
response to radiation
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
cellular protein-containing complex assembly
response to abiotic stimulus
protein-containing complex assembly
cellular response to stress
protein-containing complex subunit organization