RAD51B

Entrez Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rucaparib 6.5μM R08 exp520	-2.4
THZ531 0.11μM R07 exp409	-2.05
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.02
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.98
Bisphenol S 100μM R08 exp458	-1.92
Prochlorperazine 5.2μM R02 exp77	-1.92
Etoposide 0.1μM R05 exp198	-1.88
Genistein 15μM R07 exp360	-1.86
Olaparib 4μM R08 exp512	-1.84
Tubastatin-A 2.5μM R07 exp417	-1.83
Campthothecin 0.001μM R06 exp270	-1.77
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rad51B-Rad51C-Rad51D-XRCC2 complex
four-way junction DNA binding
replication fork
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of cell cycle G2/M phase transition
DNA-dependent ATPase activity
reciprocal meiotic recombination
homologous recombination
positive regulation of mitotic cell cycle phase transition
positive regulation of cell cycle phase transition
double-strand break repair via homologous recombination
recombinational repair
double-stranded DNA binding
single-stranded DNA binding
meiosis I
meiosis I cell cycle process
positive regulation of mitotic cell cycle
meiotic nuclear division
meiotic cell cycle process
double-strand break repair
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
DNA recombination
meiotic cell cycle
nuclear division
positive regulation of cell cycle process
blood coagulation
coagulation
hemostasis
organelle fission
positive regulation of cell cycle
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
wound healing
regulation of body fluid levels
DNA repair
response to wounding
regulation of mitotic cell cycle
DNA metabolic process
regulation of cell cycle process