CNGA1
Gene Information
- Official Symbol: CNGA1
- Official Name: cyclic nucleotide gated channel subunit alpha 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1259
- UniProt: P29973
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
- UniProt Summary: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11252
- Expression level (log2 read counts): -0.46
CNGA1 Expression in NALM6 Cells: -0.46
