CNP
Gene Information
- Official Symbol: CNP
- Official Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
- Aliases and Previous Symbols: N/A
- Entrez ID: 1267
- UniProt: P09543
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| CNPase |
GO Terms
| 2,3-cyclic-nucleotide 3-phosphodiesterase activity |
| cyclic nucleotide binding |
| myelin sheath abaxonal region |
| myelin sheath adaxonal region |
| cyclic nucleotide catabolic process |
| pseudopodium |
| cyclic nucleotide metabolic process |
| substantia nigra development |
| neural nucleus development |
| microvillus |
| nucleotide catabolic process |
| oligodendrocyte differentiation |
| regulation of mitochondrial membrane permeability |
| nucleoside phosphate catabolic process |
| adult locomotory behavior |
| regulation of membrane permeability |
| midbrain development |
| melanosome |
| nucleobase-containing small molecule biosynthetic process |
| organophosphate catabolic process |
| mitochondrial membrane organization |
| adult behavior |
| mitochondrial outer membrane |
| glial cell differentiation |
| locomotory behavior |
| gliogenesis |
| mitochondrial transport |
| aging |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| axonogenesis |
| nucleobase-containing compound catabolic process |
| forebrain development |
| mitochondrial inner membrane |
| axon development |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| cell morphogenesis involved in neuron differentiation |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| trans-synaptic signaling |
| mitochondrion organization |
| aromatic compound catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| synaptic signaling |
| microtubule cytoskeleton organization |
| neuron projection morphogenesis |
| organic cyclic compound catabolic process |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| response to toxic substance |
| cell part morphogenesis |
| nucleobase-containing small molecule metabolic process |
| cell morphogenesis involved in differentiation |
| behavior |
| small molecule biosynthetic process |
| neuron projection development |
| microtubule-based process |
| response to bacterium |
| perinuclear region of cytoplasm |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| cellular component morphogenesis |
| response to lipid |
| membrane organization |
| organophosphate metabolic process |
| central nervous system development |
| neuron differentiation |
| nucleobase-containing compound biosynthetic process |
| cytoskeleton organization |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| RNA binding |
| generation of neurons |
| response to oxygen-containing compound |
| extracellular space |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| cell development |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Q15 2.7μM R02 exp79 | -1.97 |
| UM0130462 0.025 to 0.035μM day4 R05 exp247 | -1.73 |
| PNU96415E 10μM R03 exp145 | 1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12634
- Expression level (log2 read counts): 6.45
Expression Distribution
CNP Expression in NALM6 Cells: 6.45
