CXCL10
Gene Information
- Official Symbol: CXCL10
- Official Name: C-X-C motif chemokine ligand 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 3627
- UniProt: P02778
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Pfam Domains GO Terms
Pfam Domains
| IL8 |
GO Terms
| negative regulation of myoblast fusion |
| negative regulation of syncytium formation by plasma membrane fusion |
| CXCR3 chemokine receptor binding |
| regulation of endothelial tube morphogenesis |
| cAMP-dependent protein kinase regulator activity |
| endothelial cell activation |
| T cell chemotaxis |
| regulation of T cell chemotaxis |
| positive regulation of monocyte chemotaxis |
| negative regulation of myotube differentiation |
| regulation of myoblast fusion |
| positive regulation of mononuclear cell migration |
| negative regulation of myoblast differentiation |
| regulation of monocyte chemotaxis |
| regulation of lymphocyte chemotaxis |
| response to auditory stimulus |
| T cell migration |
| regulation of syncytium formation by plasma membrane fusion |
| response to vitamin D |
| positive regulation of T cell migration |
| chemoattractant activity |
| positive regulation of lymphocyte migration |
| negative regulation of striated muscle cell differentiation |
| positive regulation of release of sequestered calcium ion into cytosol |
| regulation of T cell migration |
| regulation of mononuclear cell migration |
| lymphocyte chemotaxis |
| positive chemotaxis |
| chemokine activity |
| response to cold |
| regulation of myoblast differentiation |
| positive regulation of calcium ion transport into cytosol |
| negative regulation of muscle cell differentiation |
| response to gamma radiation |
| regulation of myotube differentiation |
| regulation of lymphocyte migration |
| antimicrobial humoral immune response mediated by antimicrobial peptide |
| lymphocyte migration |
| positive regulation of calcium ion transmembrane transport |
| cellular response to heat |
| regulation of release of sequestered calcium ion into cytosol |
| chemokine-mediated signaling pathway |
| neutrophil chemotaxis |
| response to vitamin |
| positive regulation of leukocyte chemotaxis |
| granulocyte chemotaxis |
| cellular response to chemokine |
| response to chemokine |
| neutrophil migration |
| regulation of calcium ion transport into cytosol |
| granulocyte migration |
| regulation of striated muscle cell differentiation |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| response to heat |
| antimicrobial humoral response |
| regulation of leukocyte chemotaxis |
| negative regulation of vasculature development |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| myeloid leukocyte migration |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| positive regulation of leukocyte migration |
| positive regulation of chemotaxis |
| positive regulation of cation transmembrane transport |
| leukocyte chemotaxis |
| regulation of calcium ion transmembrane transport |
| cAMP-mediated signaling |
| response to ionizing radiation |
| regulation of muscle cell differentiation |
| positive regulation of ion transmembrane transport |
| heparin binding |
| cyclic-nucleotide-mediated signaling |
| response to temperature stimulus |
| regulation of morphogenesis of an epithelium |
| cellular response to lipopolysaccharide |
| cellular response to molecule of bacterial origin |
| defense response to virus |
| regulation of leukocyte migration |
| positive regulation of transmembrane transport |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| cell chemotaxis |
| regulation of chemotaxis |
| response to mechanical stimulus |
| response to nutrient |
| cellular response to biotic stimulus |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of calcium ion transport |
| positive regulation of ion transport |
| response to virus |
| positive regulation of cytosolic calcium ion concentration |
| regulation of angiogenesis |
| muscle organ development |
| response to lipopolysaccharide |
| regulation of vasculature development |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| signaling receptor binding |
| second-messenger-mediated signaling |
| humoral immune response |
| leukocyte migration |
| regulation of metal ion transport |
| blood circulation |
| external side of plasma membrane |
| circulatory system process |
| cellular calcium ion homeostasis |
| response to radiation |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| muscle structure development |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| inflammatory response |
| response to nutrient levels |
| positive regulation of cell migration |
| cellular response to lipid |
| positive regulation of cell motility |
| response to extracellular stimulus |
| positive regulation of cellular component movement |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| response to bacterium |
| regulation of ion transport |
| negative regulation of cellular component organization |
| cation homeostasis |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of cell migration |
| response to lipid |
| regulation of kinase activity |
| cellular homeostasis |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| response to organic cyclic compound |
| negative regulation of developmental process |
| defense response to other organism |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| cell activation |
| localization of cell |
| cell motility |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of immune system process |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Quinacrine 2.5μM R03 exp146 | 2.43 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15600
- Expression level (log2 read counts): -7.68
Expression Distribution
CXCL10 Expression in NALM6 Cells: -7.68
