CYP4B1
Gene Information
- Official Symbol: CYP4B1
- Official Name: cytochrome P450 family 4 subfamily B member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1580
- UniProt: P13584
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016].
- UniProt Summary: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4441
- Expression level (log2 read counts): -1.13
CYP4B1 Expression in NALM6 Cells: -1.13
