CYP8B1
Gene Information
- Official Symbol: CYP8B1
- Official Name: cytochrome P450 family 8 subfamily B member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1582
- UniProt: Q9UNU6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008].
- UniProt Summary: Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. {ECO:0000250|UniProtKB:O02766}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6441
- Expression level (log2 read counts): 1.22
CYP8B1 Expression in NALM6 Cells: 1.22
