DBNL
Gene Information
- Official Symbol: DBNL
- Official Name: drebrin like
- Aliases and Previous Symbols: N/A
- Entrez ID: 28988
- UniProt: Q9UJU6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Cofilin ADF |
| SH3 1 |
GO Terms
| podosome assembly |
| site of polarized growth |
| ruffle assembly |
| postsynaptic actin cytoskeleton organization |
| postsynaptic cytoskeleton organization |
| positive regulation of dendritic spine morphogenesis |
| Rac protein signal transduction |
| ruffle organization |
| podosome |
| positive regulation of dendrite morphogenesis |
| activation of JUN kinase activity |
| positive regulation of dendritic spine development |
| positive regulation of axon extension |
| regulation of dendritic spine morphogenesis |
| enzyme activator activity |
| cortical actin cytoskeleton |
| clathrin-coated vesicle membrane |
| tertiary granule lumen |
| positive regulation of JUN kinase activity |
| positive regulation of dendrite development |
| regulation of dendritic spine development |
| actin filament |
| JNK cascade |
| positive regulation of axonogenesis |
| regulation of JUN kinase activity |
| postsynapse organization |
| regulation of dendrite morphogenesis |
| ruffle |
| synapse assembly |
| regulation of axon extension |
| regulation of postsynapse organization |
| stress-activated MAPK cascade |
| regulation of extent of cell growth |
| secretory granule lumen |
| ficolin-1-rich granule lumen |
| cell cortex |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| regulation of dendrite development |
| positive regulation of cell morphogenesis involved in differentiation |
| activation of MAPK activity |
| positive regulation of cell growth |
| regulation of actin filament polymerization |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| positive regulation of developmental growth |
| lamellipodium |
| regulation of cell size |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| regulation of axonogenesis |
| regulation of JNK cascade |
| protein C-terminus binding |
| postsynaptic membrane |
| actin filament binding |
| regulation of synapse organization |
| regulation of protein polymerization |
| regulation of synapse structure or activity |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| receptor-mediated endocytosis |
| protein domain specific binding |
| Ras protein signal transduction |
| postsynaptic density |
| early endosome |
| positive regulation of growth |
| regulation of actin filament organization |
| positive regulation of MAP kinase activity |
| actin binding |
| synapse organization |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| cadherin binding |
| small GTPase mediated signal transduction |
| activation of protein kinase activity |
| regulation of developmental growth |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| positive regulation of neuron differentiation |
| MAPK cascade |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| signal transduction by protein phosphorylation |
| regulation of cell growth |
| dendrite |
| plasma membrane bounded cell projection assembly |
| regulation of protein complex assembly |
| cell projection assembly |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| neutrophil degranulation |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| neutrophil activation involved in immune response |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| cell part morphogenesis |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| cell junction |
| endocytosis |
| actin filament-based process |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| adaptive immune response |
| Golgi membrane |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| neuron projection development |
| regulation of growth |
| import into cell |
| regulation of plasma membrane bounded cell projection organization |
| regulated exocytosis |
| regulation of cell projection organization |
| cell morphogenesis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| organelle assembly |
| leukocyte mediated immunity |
| exocytosis |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of kinase activity |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| secretion by cell |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| export from cell |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| immune effector process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| phosphorylation |
| regulation of organelle organization |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Wiskostatin 3μM R07 exp422 | -1.73 |
| Metformin 40μM R03 exp132 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7671
- Expression level (log2 read counts): 7.52
Expression Distribution
DBNL Expression in NALM6 Cells: 7.52
