DEGS1

Entrez Summary: N/A
UniProt Summary: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). {ECO:0000269|PubMed:11937514}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	1.72
Clomiphene 4.4μM R02 exp68	1.77
Staurosporine 0.02μM R08 exp524	1.77
MLN-4924 0.2μM R00 exp21	1.8
Nocodazole 0.02μM R00 exp23	1.87
Azithromycin 100μM R08 exp452	1.88
Momordin-Ic 10μM R08 exp506	1.88
Vemurafenib 6.6μM R02 exp89	1.96
5-Fluorouracil 20μM R00 exp2	1.97
THZ531 0.11μM R07 exp409	2.01
MLN-4924 2μM R00 exp22	2.06
Colchicine 0.009μM R05 exp215	2.24
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.48
Pyridostatin 4μM R05 exp240	2.52
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.7
Vincristine 0.0005μM R04 exp190	2.71
THZ531 0.225μM R08 exp444	3.14
Tubacin 1.6μM R07 exp416	4

Gene	Correlation
HARS	0.442

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution