DGKQ
Gene Information
- Official Symbol: DGKQ
- Official Name: diacylglycerol kinase theta
- Aliases and Previous Symbols: N/A
- Entrez ID: 1609
- UniProt: P52824
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:17664281}.
Pfam Domains GO Terms
Pfam Domains
| DAGK acc |
| RA |
| C1 1 |
| DAGK cat |
GO Terms
| regulation of progesterone biosynthetic process |
| regulation of cortisol biosynthetic process |
| transmembrane receptor protein tyrosine kinase activator activity |
| regulation of glucocorticoid biosynthetic process |
| thrombin-activated receptor signaling pathway |
| regulation of glucocorticoid metabolic process |
| regulation of steroid hormone biosynthetic process |
| diacylglycerol kinase activity |
| activation of transmembrane receptor protein tyrosine kinase activity |
| protein kinase C signaling |
| phospholipase binding |
| regulation of ketone biosynthetic process |
| regulation of synaptic vesicle endocytosis |
| NAD+ kinase activity |
| negative regulation of peptidyl-threonine phosphorylation |
| diacylglycerol metabolic process |
| regulation of synaptic vesicle recycling |
| regulation of hormone biosynthetic process |
| protein kinase C-activating G protein-coupled receptor signaling pathway |
| vesicle membrane |
| response to ATP |
| activating transcription factor binding |
| regulation of hormone metabolic process |
| regulation of TORC1 signaling |
| phosphatidic acid biosynthetic process |
| phosphatidic acid metabolic process |
| regulation of peptidyl-threonine phosphorylation |
| regulation of gluconeogenesis |
| regulation of cholesterol metabolic process |
| lipid phosphorylation |
| regulation of alcohol biosynthetic process |
| postsynapse |
| regulation of steroid biosynthetic process |
| kinase binding |
| presynapse |
| regulation of carbohydrate biosynthetic process |
| response to cAMP |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| regulation of TOR signaling |
| nuclear matrix |
| regulation of synaptic vesicle cycle |
| regulation of glucose metabolic process |
| regulation of steroid metabolic process |
| response to organophosphorus |
| platelet activation |
| regulation of cellular carbohydrate metabolic process |
| regulation of G protein-coupled receptor signaling pathway |
| cAMP-mediated signaling |
| response to purine-containing compound |
| regulation of cellular ketone metabolic process |
| cyclic-nucleotide-mediated signaling |
| peptidyl-serine phosphorylation |
| regulation of lipid biosynthetic process |
| positive regulation of peptidyl-tyrosine phosphorylation |
| peptidyl-serine modification |
| lipid modification |
| regulation of carbohydrate metabolic process |
| regulation of endocytosis |
| glycerophospholipid biosynthetic process |
| response to nutrient |
| glycerolipid biosynthetic process |
| phospholipid biosynthetic process |
| regulation of peptidyl-tyrosine phosphorylation |
| endosome |
| blood coagulation |
| coagulation |
| hemostasis |
| glycerophospholipid metabolic process |
| activation of protein kinase activity |
| second-messenger-mediated signaling |
| glutamatergic synapse |
| cytoskeleton |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| regulation of lipid metabolic process |
| nuclear speck |
| negative regulation of protein phosphorylation |
| regulation of small molecule metabolic process |
| negative regulation of phosphorylation |
| wound healing |
| regulation of body fluid levels |
| response to nutrient levels |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| response to extracellular stimulus |
| regulation of hormone levels |
| positive regulation of protein kinase activity |
| organophosphate biosynthetic process |
| regulation of vesicle-mediated transport |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| response to wounding |
| positive regulation of kinase activity |
| lipid biosynthetic process |
| negative regulation of protein modification process |
| positive regulation of transferase activity |
| enzyme linked receptor protein signaling pathway |
| regulation of protein kinase activity |
| cellular protein-containing complex assembly |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| organophosphate metabolic process |
| regulation of cellular localization |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| protein phosphorylation |
| regulation of transferase activity |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| response to drug |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| cell activation |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| lipid metabolic process |
| positive regulation of protein modification process |
| phosphorylation |
| G protein-coupled receptor signaling pathway |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| ATP binding |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-6727 0.04μM R03 exp98 | -1.81 |
| TNF-alpha 44ng/ml R08 exp533 | 1.84 |
| UM0129480 7μM R02 exp85 | 1.9 |
| Milciclib 2μM R08 exp502 | 3.22 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.464 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5910
- Expression level (log2 read counts): 4.64
Expression Distribution
DGKQ Expression in NALM6 Cells: 4.64
