DNAH8
Gene Information
- Official Symbol: DNAH8
- Official Name: dynein axonemal heavy chain 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 1769
- UniProt: Q96JB1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012].
- UniProt Summary: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12437
- Expression level (log2 read counts): -4.6
DNAH8 Expression in NALM6 Cells: -4.6
