ETV5
Gene Information
- Official Symbol: ETV5
- Official Name: ETS variant transcription factor 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 2119
- UniProt: P41161
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. {ECO:0000269|PubMed:8152800}.
Pfam Domains GO Terms
Pfam Domains
| ETS PEA3 N |
| Ets |
GO Terms
| germline stem cell asymmetric division |
| male germ-line stem cell asymmetric division |
| germ-line stem cell division |
| regulation of branching involved in mammary gland duct morphogenesis |
| skeletal muscle acetylcholine-gated channel clustering |
| asymmetric stem cell division |
| positive regulation of glial cell proliferation |
| asymmetric cell division |
| postsynaptic membrane organization |
| regulation of glial cell proliferation |
| neuromuscular synaptic transmission |
| stem cell division |
| neuromuscular junction development |
| receptor clustering |
| regulation of morphogenesis of a branching structure |
| positive regulation of gliogenesis |
| localization within membrane |
| postsynapse organization |
| regulation of gliogenesis |
| regulation of morphogenesis of an epithelium |
| locomotory behavior |
| transcription regulatory region DNA binding |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| cellular response to oxidative stress |
| germ cell development |
| regulation of animal organ morphogenesis |
| synapse organization |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| cellular process involved in reproduction in multicellular organism |
| positive regulation of neuron differentiation |
| response to oxidative stress |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| trans-synaptic signaling |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| synaptic signaling |
| positive regulation of neurogenesis |
| protein localization to membrane |
| cell division |
| positive regulation of nervous system development |
| positive regulation of cell development |
| spermatogenesis |
| male gamete generation |
| behavior |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| gamete generation |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| membrane organization |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| multi-organism reproductive process |
| regulation of anatomical structure morphogenesis |
| cell-cell signaling |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| DNA binding |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| cellular protein localization |
| cellular macromolecule localization |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| cellular response to stress |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| NFN1 0.1μM R01 exp49 | -2.26 |
| CAY10603 0.55μM R08 exp467 | -1.94 |
| S-DABN 8μM R03 exp112 | 1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13296
- Expression level (log2 read counts): 3.99
Expression Distribution
ETV5 Expression in NALM6 Cells: 3.99
