FABP1
Gene Information
- Official Symbol: FABP1
- Official Name: fatty acid binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2168
- UniProt: P07148
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). {ECO:0000250|UniProtKB:P82289, ECO:0000269|PubMed:25732850}.
Pfam Domains GO Terms
Pfam Domains
| Lipocalin |
GO Terms
| apical cortex |
| bile acid binding |
| positive regulation of fatty acid beta-oxidation |
| long-chain fatty acid transporter activity |
| positive regulation of fatty acid oxidation |
| regulation of fatty acid beta-oxidation |
| antioxidant activity |
| fatty acid binding |
| positive regulation of lipid catabolic process |
| triglyceride catabolic process |
| regulation of fatty acid oxidation |
| intestinal absorption |
| positive regulation of fatty acid metabolic process |
| neutral lipid catabolic process |
| acylglycerol catabolic process |
| peroxisomal matrix |
| glycerolipid catabolic process |
| regulation of lipid catabolic process |
| drug binding |
| long-chain fatty acid transport |
| cellular response to hydrogen peroxide |
| fatty acid transport |
| digestive system process |
| triglyceride metabolic process |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of fatty acid metabolic process |
| cellular oxidant detoxification |
| negative regulation of cysteine-type endopeptidase activity |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| cellular detoxification |
| phospholipid binding |
| digestion |
| cellular response to antibiotic |
| response to hydrogen peroxide |
| detoxification |
| cellular response to reactive oxygen species |
| monocarboxylic acid transport |
| positive regulation of small molecule metabolic process |
| positive regulation of lipid metabolic process |
| regulation of cellular ketone metabolic process |
| cellular response to hypoxia |
| response to reactive oxygen species |
| cellular lipid catabolic process |
| cellular response to decreased oxygen levels |
| cellular response to toxic substance |
| cellular response to oxygen levels |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to oxidative stress |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| organic acid transport |
| carboxylic acid transport |
| lipid transport |
| lipid catabolic process |
| response to antibiotic |
| lipid localization |
| response to hypoxia |
| negative regulation of proteolysis |
| response to decreased oxygen levels |
| positive regulation of cellular catabolic process |
| glycerolipid metabolic process |
| response to oxygen levels |
| response to oxidative stress |
| chromatin binding |
| regulation of lipid metabolic process |
| cellular response to drug |
| regulation of endopeptidase activity |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| organic anion transport |
| response to toxic substance |
| response to inorganic substance |
| anion transport |
| protein-containing complex |
| regulation of proteolysis |
| positive regulation of hydrolase activity |
| negative regulation of catalytic activity |
| regulation of cellular catabolic process |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| cellular lipid metabolic process |
| regulation of catabolic process |
| negative regulation of cell death |
| response to drug |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| lipid metabolic process |
| regulation of hydrolase activity |
| ion transport |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of cell death |
| cellular response to stress |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13446
- Expression level (log2 read counts): -7.68
Expression Distribution
FABP1 Expression in NALM6 Cells: -7.68
