FAM49B
Gene Information
- Official Symbol: CYRIB
- Official Name: CYFIP related Rac1 interactor B
- Aliases and Previous Symbols: N/A
- Entrez ID: 51571
- UniProt: Q9NUQ9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DUF1394 |
GO Terms
| regulation of memory T cell activation |
| positive regulation of memory T cell activation |
| MHC class Ib protein binding, via antigen binding groove |
| positive regulation of T cell mediated cytotoxicity |
| regulation of T cell mediated cytotoxicity |
| positive regulation of T cell mediated immunity |
| positive regulation of leukocyte mediated cytotoxicity |
| positive regulation of interferon-gamma production |
| positive regulation of cell killing |
| platelet alpha granule lumen |
| regulation of T cell mediated immunity |
| regulation of leukocyte mediated cytotoxicity |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of cell killing |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| platelet degranulation |
| positive regulation of leukocyte mediated immunity |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of lymphocyte mediated immunity |
| regulation of adaptive immune response |
| cilium |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| positive regulation of cell-cell adhesion |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| positive regulation of lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| positive regulation of cytokine production |
| regulation of immune effector process |
| regulation of lymphocyte activation |
| regulation of leukocyte activation |
| regulation of cell activation |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulated exocytosis |
| exocytosis |
| positive regulation of immune response |
| secretion by cell |
| export from cell |
| secretion |
| positive regulation of immune system process |
| regulation of immune response |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vemurafenib 6.6μM R08 exp434 | -1.76 |
| RO-3306 3 to 4μM on day4 R04 exp165 | 1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17836
- Expression level (log2 read counts): 6.65
Expression Distribution
FAM49B Expression in NALM6 Cells: 6.65
