FURIN
Gene Information
- Official Symbol: FURIN
- Official Name: furin, paired basic amino acid cleaving enzyme
- Aliases and Previous Symbols: N/A
- Entrez ID: 5045
- UniProt: P09958
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. {ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:1629222, ECO:0000269|PubMed:1713771, ECO:0000269|PubMed:2251280, ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0000269|PubMed:7592877, ECO:0000269|PubMed:7690548, ECO:0000269|PubMed:9130696}. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. {ECO:0000269|PubMed:25974265}.
Pfam Domains GO Terms
Pfam Domains
| P proprotein |
| Peptidase S8 |
GO Terms
| dibasic protein processing |
| regulation of transforming growth factor beta1 activation |
| regulation of nerve growth factor production |
| positive regulation of transforming growth factor beta activation |
| viral protein processing |
| negative regulation of nerve growth factor production |
| positive regulation of transforming growth factor beta1 activation |
| neurotrophin production |
| nerve growth factor production |
| negative regulation of neurotrophin production |
| regulation of neurotrophin production |
| negative regulation of low-density lipoprotein particle receptor catabolic process |
| nerve growth factor processing |
| negative regulation of receptor catabolic process |
| nerve growth factor binding |
| negative regulation of transforming growth factor beta1 production |
| regulation of low-density lipoprotein particle receptor catabolic process |
| positive regulation of transforming growth factor beta1 production |
| regulation of transforming growth factor beta activation |
| negative regulation of transforming growth factor beta production |
| regulation of low-density lipoprotein particle receptor biosynthetic process |
| regulation of receptor catabolic process |
| regulation of transforming growth factor beta1 production |
| signal peptide processing |
| positive regulation of membrane protein ectodomain proteolysis |
| trans-Golgi network transport vesicle |
| positive regulation of transforming growth factor beta production |
| regulation of lipoprotein lipase activity |
| regulation of receptor biosynthetic process |
| regulation of membrane protein ectodomain proteolysis |
| peptide hormone processing |
| regulation of transforming growth factor beta production |
| zymogen activation |
| collagen catabolic process |
| peptide binding |
| integral component of Golgi membrane |
| collagen metabolic process |
| extracellular matrix disassembly |
| endopeptidase activity |
| peptidase activity |
| negative regulation of cellular protein catabolic process |
| serine-type endopeptidase inhibitor activity |
| regulation of lipase activity |
| Golgi lumen |
| protease binding |
| transforming growth factor beta receptor signaling pathway |
| cornification |
| viral gene expression |
| negative regulation of protein catabolic process |
| cellular response to transforming growth factor beta stimulus |
| protein processing |
| response to transforming growth factor beta |
| serine-type endopeptidase activity |
| trans-Golgi network |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| viral life cycle |
| hormone metabolic process |
| endosome membrane |
| positive regulation of protein catabolic process |
| membrane raft |
| protein maturation |
| keratinization |
| negative regulation of endopeptidase activity |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| negative regulation of peptidase activity |
| negative regulation of cytokine production |
| keratinocyte differentiation |
| negative regulation of catabolic process |
| epidermal cell differentiation |
| extracellular matrix organization |
| negative regulation of proteolysis |
| positive regulation of proteolysis |
| positive regulation of cellular catabolic process |
| skin development |
| regulation of protein catabolic process |
| extracellular structure organization |
| cellular component disassembly |
| peptide biosynthetic process |
| epidermis development |
| regulation of endopeptidase activity |
| positive regulation of catabolic process |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| negative regulation of hydrolase activity |
| cellular response to growth factor stimulus |
| amide biosynthetic process |
| peptide metabolic process |
| response to growth factor |
| regulation of hormone levels |
| cell surface |
| Golgi membrane |
| epithelial cell differentiation |
| regulation of cytokine production |
| viral process |
| enzyme linked receptor protein signaling pathway |
| regulation of proteolysis |
| symbiotic process |
| cellular amide metabolic process |
| negative regulation of catalytic activity |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| regulation of catabolic process |
| secretion by cell |
| endoplasmic reticulum |
| negative regulation of cellular protein metabolic process |
| export from cell |
| programmed cell death |
| cell death |
| negative regulation of protein metabolic process |
| epithelium development |
| secretion |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| proteolysis |
| regulation of hydrolase activity |
| organonitrogen compound biosynthetic process |
| response to endogenous stimulus |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| extracellular region |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Wortmannin 5μM R00 exp38 | -2.35 |
| Clomiphene 4.4μM R02 exp68 | -1.77 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 12/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 6/15 |
| prostate | 1/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5297
- Expression level (log2 read counts): 3.4
Expression Distribution
FURIN Expression in NALM6 Cells: 3.4
