FZD7
Gene Information
- Official Symbol: FZD7
- Official Name: frizzled class receptor 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 8324
- UniProt: O75084
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Pfam Domains GO Terms
Pfam Domains
| Fz |
| Frizzled |
GO Terms
| negative regulation of ectoderm development |
| negative regulation of ectodermal cell fate specification |
| regulation of ectoderm development |
| regulation of ectodermal cell fate specification |
| skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration |
| non-canonical Wnt signaling pathway via JNK cascade |
| non-canonical Wnt signaling pathway via MAPK cascade |
| negative regulation of cell fate specification |
| negative regulation of gastrulation |
| positive regulation of epithelial cell proliferation involved in wound healing |
| regulation of cell fate specification |
| negative regulation of cell fate commitment |
| mesenchymal to epithelial transition |
| negative regulation of cardiac muscle cell differentiation |
| Wnt-activated receptor activity |
| negative regulation of cardiocyte differentiation |
| somatic stem cell division |
| negative regulation of embryonic development |
| regulation of cell fate commitment |
| negative regulation of cardiac muscle tissue development |
| stem cell division |
| skeletal muscle tissue regeneration |
| regulation of cardiac muscle cell differentiation |
| Wnt-protein binding |
| regulation of gastrulation |
| negative regulation of striated muscle cell differentiation |
| frizzled binding |
| T cell differentiation in thymus |
| negative regulation of striated muscle tissue development |
| negative regulation of muscle organ development |
| regulation of cardiocyte differentiation |
| negative regulation of muscle tissue development |
| substrate adhesion-dependent cell spreading |
| negative regulation of muscle cell differentiation |
| negative regulation of cell-substrate adhesion |
| tissue regeneration |
| cellular response to retinoic acid |
| phosphatidylinositol-4,5-bisphosphate binding |
| regulation of cardiac muscle tissue development |
| recycling endosome membrane |
| PDZ domain binding |
| canonical Wnt signaling pathway |
| Wnt signaling pathway, planar cell polarity pathway |
| regulation of striated muscle cell differentiation |
| response to retinoic acid |
| regulation of establishment of planar polarity |
| regulation of embryonic development |
| regulation of striated muscle tissue development |
| non-canonical Wnt signaling pathway |
| regulation of muscle tissue development |
| stem cell population maintenance |
| T cell differentiation |
| regulation of muscle organ development |
| maintenance of cell number |
| positive regulation of JNK cascade |
| regulation of muscle cell differentiation |
| regeneration |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| regulation of morphogenesis of an epithelium |
| cell-substrate adhesion |
| regulation of JNK cascade |
| positive regulation of epithelial cell proliferation |
| cellular response to acid chemical |
| regulation of cell-substrate adhesion |
| regulation of stress-activated MAPK cascade |
| T cell activation |
| regulation of stress-activated protein kinase signaling cascade |
| lymphocyte differentiation |
| regulation of animal organ morphogenesis |
| negative regulation of cell adhesion |
| regulation of canonical Wnt signaling pathway |
| leukocyte differentiation |
| regulation of epithelial cell proliferation |
| response to acid chemical |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| regulation of Wnt signaling pathway |
| lymphocyte activation |
| developmental growth |
| growth |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| wound healing |
| cell division |
| cellular response to lipid |
| positive regulation of MAPK cascade |
| hemopoiesis |
| cell morphogenesis involved in differentiation |
| response to wounding |
| hematopoietic or lymphoid organ development |
| immune system development |
| epithelial cell differentiation |
| regulation of cell adhesion |
| negative regulation of cell differentiation |
| cell morphogenesis |
| G protein-coupled receptor activity |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| cellular component morphogenesis |
| response to lipid |
| positive regulation of cell population proliferation |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| negative regulation of developmental process |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| G protein-coupled receptor signaling pathway |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Salubrinal 20μM R07 exp399 | -1.73 |
| Chlorpromazine 10μM R07 exp344 | 1.88 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14733
- Expression level (log2 read counts): 3.06
Expression Distribution
FZD7 Expression in NALM6 Cells: 3.06
